Andrew J Shepherd
Overview
Explore the profile of Andrew J Shepherd including associated specialties, affiliations and a list of published articles.
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40
Citations
712
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Recent Articles
1.
Vichare R, Kulahci Y, McCallin R, Zor F, Selek F, Liu L, et al.
J Nanobiotechnology
. 2025 Feb;
23(1):80.
PMID: 39905487
In inflammatory diseases or following an injury, dysregulated inflammation is a common driver of pain and tissue damage. Macrophages are immune cells that contribute to the initiation, maintenance, and resolution...
2.
McIlvried L, Del Rosario J, Pullen M, Wangzhou A, Sheahan T, Shepherd A, et al.
J Gen Physiol
. 2024 Dec;
157(1).
PMID: 39688836
In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths....
3.
Casaril A, Gaffney C, Shepherd A
Int Rev Neurobiol
. 2024 Nov;
179:339-401.
PMID: 39580217
Animal models continue to be crucial to developing our understanding of the molecular, cellular, and neurophysiological mechanisms that lead to neuropathic pain. The overwhelming majority of animal studies use rodent...
4.
Avery T, Li J, Turner D, Rasheed M, Cherry F, Stachura D, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39496929
Treatment of diseases of oxidative stress through activation of the antioxidant nuclear factor E2-related factor 2 (NRF2) is limited by systemic side effects. We chemically functionalize the NRF2 activator monomethyl...
5.
Das A, Nichols J, Crelli C, Liu L, Vichare R, Pham H, et al.
Sci Rep
. 2024 Aug;
14(1):18978.
PMID: 39152212
A major and irreversible complication of diabetes is diabetic peripheral neuropathy (DPN), which can lead to significant disability and decreased quality of life. Prior work demonstrates the peptide hormone Angiotensin...
6.
Cortez I, Gaffney C, Vichare R, Crelli C, Liu L, Lee E, et al.
Int J Nanomedicine
. 2024 Jul;
19:7253-7271.
PMID: 39050880
Soft tissue injuries often involve muscle and peripheral nerves and are qualitatively distinct from single-tissue injuries. Prior research suggests that damaged innervation compromises wound healing. To test this in a...
7.
Willoughby J, Dou L, Bhattacharya S, Jackson H, Seestaller-Wehr L, Kilian D, et al.
J Immunother Cancer
. 2024 Jul;
12(7).
PMID: 38964788
Background: OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here,...
8.
Nichols J, Pham H, Lee E, Mahalingam R, Shepherd A
Cell Mol Life Sci
. 2024 Mar;
81(1):146.
PMID: 38502310
Complications associated with Type 1 and Type 2 diabetes, such as diabetic peripheral neuropathy and diabetic foot ulcers, are a growing health-care concern. In addition, this concern increases as diabetic...
9.
10.
Shepherd A, Rice A, Smith M
Curr Opin Pharmacol
. 2023 Dec;
73:102415.
PMID: 38041933
Translating promising preclinical pain relief data for novel molecules from drug discovery to positive clinical trial outcomes is challenging. The angiotensin II type 2 (AT) receptor is a clinically-validated target...