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Andrew J Levine

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Articles 67
Citations 2152
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Recent Articles
1.
Levine A, Thadani C, Soontornniyomkij V, Lopez-Aranda M, Mesa Y, Kitchen S, et al.
Res Sq . 2024 Jan; PMID: 38168407
Methods: We conducted three studies to assess the efficacy of CDDO-Me alone or in combination with antiretroviral therapy in humanized mice infected with HIV; behavioral, histopathological, and immunohistochemical. Results: CDDO-Me...
2.
Fisher A, Moore D, Levine A, Masliah E, Gouaux B, Soontornniyomkij V, et al.
J Neurovirol . 2023 Nov; 29(6):713-722. PMID: 37943478
We examined whether cognitive reserve moderated the relationship between neurodegeneration and cognition in 67 postmortem persons with HIV (PWH) who were cognitively assessed within 1 year of death. Cognitive reserve...
3.
Horvath S, Singh K, Raj K, Khairnar S, Sanghavi A, Shrivastava A, et al.
Geroscience . 2023 Oct; 46(1):367-394. PMID: 37875652
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat...
4.
Horvath S, Singh K, Raj K, Khairnar S, Sanghavi A, Shrivastava A, et al.
bioRxiv . 2023 Aug; PMID: 37609328
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young pigs rejuvenates old rat tissues...
5.
Haghani A, Li C, Robeck T, Zhang J, Lu A, Ablaeva J, et al.
Science . 2023 Aug; 381(6658):eabq5693. PMID: 37561875
Using DNA methylation profiles ( = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we...
6.
Heany S, Levine A, Lesosky M, Phillips N, Fouche J, Myer L, et al.
J Neurovirol . 2023 May; 29(3):272-282. PMID: 37179258
We have previously shown accelerated ageing in adolescents perinatally infected with HIV (PHIV +), based on discrepancies between epigenetic and chronological age. The current study examines follow-up longitudinal patterns of...
7.
Horvath S, Lin D, Kobor M, Zoller J, Said J, Morgello S, et al.
Geroscience . 2022 Apr; 44(3):1609-1620. PMID: 35411474
Epigenetic clocks based on patterns of DNA methylation have great importance in understanding aging and disease; however, there are basic questions to be resolved in their application. It remains unknown...
8.
Hoare J, Stein D, Heany S, Fouche J, Phillips N, Er S, et al.
J Neurovirol . 2021 Feb; 28(2):208-216. PMID: 33554325
We recently demonstrated that adolescents perinatally infected with HIV-1 (PHIV+) have accelerated aging as measured by a highly accurate epigenetic biomarker of aging known as the epigenetic clock. However, whether...
9.
Nir T, Fouche J, Ananworanich J, Ances B, Boban J, Brew B, et al.
JAMA Netw Open . 2021 Jan; 4(1):e2031190. PMID: 33449093
Importance: Despite more widely accessible combination antiretroviral therapy (cART), HIV-1 infection remains a global public health challenge. Even in treated patients with chronic HIV infection, neurocognitive impairment often persists, affecting...
10.
Wang Z, Cheng Y, Seaberg E, Rubin L, Levine A, Becker J
Stat Med . 2020 Dec; 40(6):1440-1452. PMID: 33296952
Motivated by the Multicenter AIDS Cohort Study (MACS), we develop classification procedures for cognitive impairment based on longitudinal measures. To control family-wise error, we adapt the cross-sectional multivariate normative comparisons...