Andrew J Deans
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Explore the profile of Andrew J Deans including associated specialties, affiliations and a list of published articles.
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54
Citations
2357
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Recent Articles
11.
Cantres-Velez J, Blaize J, Vierra D, Boisvert R, Garzon J, Piraino B, et al.
Mol Cell Biol
. 2021 Jun;
41(8):e0023421.
PMID: 34096775
Fanconi anemia (FA) is a rare genetic disease characterized by increased risk for bone marrow failure and cancer. The FA proteins function together to repair damaged DNA. A central step...
12.
Sharp M, Bythell-Douglas R, Deans A, Crismani W
Mol Cell
. 2021 May;
81(11):2278-2289.
PMID: 33984284
Agents that induce DNA damage can cure some cancers. However, the side effects of chemotherapy are severe because of the indiscriminate action of DNA-damaging agents on both healthy and cancerous...
13.
14.
Bythell-Douglas R, Deans A
Structure
. 2020 Dec;
29(2):99-113.
PMID: 33357470
The Bloom syndrome complex is a DNA damage repair machine. It consists of several protein components which are functional in isolation, but interdependent in cells for the maintenance of accurate...
15.
Tan W, Deans A
Mol Cell
. 2020 Dec;
80(6):935-937.
PMID: 33338408
Two new studies in this issue of Molecular Cell demonstrate that bone marrow failure, in mice and humans, can be induced by formaldehyde generated either from defective metabolism (Dingler et ...
16.
Tan W, Deans A
Prog Biophys Mol Biol
. 2020 Oct;
163:5-13.
PMID: 33058944
The Fanconi Anemia (FA) pathway maintains genome stability by preventing DNA damage from occurring when replication is blocked. Central to the FA pathway is the monoubiquitination of FANCI-FANCD2 mediated by...
17.
Li L, Tan W, Deans A
Essays Biochem
. 2020 Jul;
64(5):807-817.
PMID: 32725171
The Fanconi anemia (FA) pathway coordinates a faithful repair mechanism for DNA damage that blocks DNA replication, such as interstrand cross-links. A key step in the FA pathway is the...
18.
Sanij E, Hannan K, Xuan J, Yan S, Ahern J, Trigos A, et al.
Nat Commun
. 2020 May;
11(1):2641.
PMID: 32457376
Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX-5461, the first-in-class inhibitor of RNA...
19.
Sharp M, Murphy V, van Twest S, Tan W, Lui J, Simpson K, et al.
Sci Rep
. 2020 May;
10(1):7959.
PMID: 32409752
DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription. ICLs can be caused by endogenous reactive metabolites or from chemotherapeutics. ICL repair...
20.
Tan W, van Twest S, Leis A, Bythell-Douglas R, Murphy V, Sharp M, et al.
Elife
. 2020 Mar;
9.
PMID: 32167469
FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathway. It has been proposed that at stalled replication forks, monoubiquitinated-FANCD2 serves to...