Andrew Hedger
Overview
Explore the profile of Andrew Hedger including associated specialties, affiliations and a list of published articles.
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3
Citations
88
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0
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Recent Articles
1.
Manik M, Pan M, Xiao L, Gu W, Kim H, Pospich S, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2418988122.
PMID: 39786929
Innate immunity relies on Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns. The TIR (Toll/interleukin-1 receptor) domain-containing TLR adaptors TRIF (TIR domain-containing adaptor-inducing interferon-β) and TRAM (TRIF-related adaptor molecule) are...
2.
Rahaman M, Thygesen S, Maxwell M, Kim H, Mudai P, Nanson J, et al.
J Enzyme Inhib Med Chem
. 2024 Feb;
39(1):2313055.
PMID: 38416868
Toll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 receptor)...
3.
Azar D, Haas M, Fedosyuk S, Rahaman M, Hedger A, Kobe B, et al.
Structure
. 2020 Oct;
28(12):1271-1287.e5.
PMID: 33035450
Vaccinia virus A46 is an anti-inflammatory and non-anti-apoptotic, two-domain member of the poxviral Bcl-2-like protein family that inhibits the cellular innate immune response at the level of the Toll/interleukin-1 receptor...
4.
Ve T, Vajjhala P, Hedger A, Croll T, DiMaio F, Horsefield S, et al.
Nat Struct Mol Biol
. 2017 Aug;
24(9):743-751.
PMID: 28759049
Toll-like receptor (TLR) signaling is a key innate immunity response to pathogens. Recruitment of signaling adapters such as MAL (TIRAP) and MyD88 to the TLRs requires Toll/interleukin-1 receptor (TIR)-domain interactions,...