Andrew H Wyllie
Overview
Explore the profile of Andrew H Wyllie including associated specialties, affiliations and a list of published articles.
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11
Citations
385
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Recent Articles
1.
Ibrahim A, Arends M, Silva A, Wyllie A, Greger L, Ito Y, et al.
Gut
. 2010 Nov;
60(4):499-508.
PMID: 21068132
Background And Aims: Although aberrant methylation of key genes in the progression of colorectal neoplasia has been reported, no model-based analysis of the incremental changes through the intermediate adenoma stage...
2.
Poulogiannis G, McIntyre R, Dimitriadi M, Apps J, Wilson C, Ichimura K, et al.
Proc Natl Acad Sci U S A
. 2010 Aug;
107(34):15145-50.
PMID: 20696900
In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin...
3.
Wyllie A
Mol Neurobiol
. 2010 Jun;
42(1):4-9.
PMID: 20552413
Apoptosis was a term introduced in 1972 to distinguish a mode of cell death with characteristic morphology and apparently regulated, endogenously driven mechanisms. The effector processes responsible for apoptosis are...
4.
Poulogiannis G, Ichimura K, Hamoudi R, Luo F, Leung S, Yuen S, et al.
J Pathol
. 2009 Nov;
220(3):338-47.
PMID: 19911421
In a study of 109 colorectal cancers, DNA copy number aberrations were identified by comparative genomic hybridization using a DNA microarray covering the entire genome at an average interval of...
5.
Ferguson B, Dovey C, Lilley K, Wyllie A, Rich T
J Proteome Res
. 2007 Apr;
6(5):2027-32.
PMID: 17419608
The marriage between transducers of cell stress stimuli and their nuclear targets is likely to be achieved in part by some spatial-temporal compartmentalization of the relevant effectors. A candidate compartment...
6.
Ibrahim A, Thorne N, Baird K, Barbosa-Morais N, Tavare S, Collins V, et al.
Nucleic Acids Res
. 2006 Oct;
34(20):e136.
PMID: 17041235
We describe an optimized microarray method for identifying genome-wide CpG island methylation called microarray-based methylation assessment of single samples (MMASS) which directly compares methylated to unmethylated sequences within a single...
7.
Dovey C, Varadaraj A, Wyllie A, Rich T
J Pathol
. 2004 Jul;
203(4):877-83.
PMID: 15258989
The polyglutamine diseases are characterized by expansion of triplet CAG repeats that encode polyglutamine tracts in otherwise unrelated proteins. One plausible explanation for the neurodegeneration of these disorders proposes that...
8.
Yuen S, Chan T, Ho J, Chan A, Chung L, Lam P, et al.
Oncogene
. 2002 Oct;
21(49):7585-92.
PMID: 12386821
High-frequency microsatellite instability (MSI-H) results from deficiency in nucleotide mismatch repair. It contributes significantly to carcinogenesis in the human colorectal mucosa. Here we study 41 colorectal and three other HNPCC-related...
9.
Wyllie A
J Pathol
. 2002 Sep;
198(2):139-41.
PMID: 12237872
E2F1 is a transcription factor involved in both cell cycle progression and apoptosis. Perhaps surprisingly, these two processes are closely related, and the choice between them appears to be made...
10.
Toft N, Curtis L, Sansom O, Leitch A, Wyllie A, Te Riele H, et al.
Oncogene
. 2002 Sep;
21(41):6299-306.
PMID: 12214270
In colorectal tumorigenesis, loss of function of the mismatch repair genes is closely associated with genomic instability at the nucleotide level whereas p53 deficiency has been linked with gross chromosomal...