Andrew H A Clayton
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Explore the profile of Andrew H A Clayton including associated specialties, affiliations and a list of published articles.
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75
Citations
1052
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Recent Articles
11.
Kabir M, Wang F, Clayton A
Int J Mol Sci
. 2021 Apr;
22(5).
PMID: 33806656
Ligand-protein binding is responsible for the vast majority of bio-molecular functions. Most experimental techniques examine the most populated ligand-bound state. The determination of less populated, intermediate, and transient bound states...
12.
Katoozi D, Clayton A, Moss D, Chon J
Biomed Opt Express
. 2021 Mar;
12(1):539-552.
PMID: 33659088
The application of gold nanoparticles (AuNPs) in cancer therapeutics and diagnostics has recently reached a clinical level. Functional use of the AuNP in theranostics first requires effective uptake into the...
13.
Shagaghi N, Clayton A, Aguilar M, Lee T, Palombo E, Bhave M
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33207639
Antimicrobial peptides (AMPs) often exhibit wide-spectrum activities and are considered ideal candidates for effectively controlling persistent and multidrug-resistant wound infections. PuroA, a synthetic peptide based on the tryptophan (Trp)-rich domain...
14.
Kabir M, Backler F, Clayton A, Wang F
Front Chem
. 2020 Aug;
8:596.
PMID: 32850633
Dacomitinib (PF-00299804) was recently approved by the Food and Drug Administration (FDA) as a tyrosine kinase inhibitor (TKI). Unfortunately, side effects and disease resistance eventually result from its use. Off-target...
15.
Ningsih Z, Clayton A
Phys Biol
. 2020 May;
17(4):044001.
PMID: 32396881
We examined PC12 cell proliferation in environments with temporally varying epidermal growth factor concentrations by means of a microfluidic system. Our measurements revealed frequency-dependent cell behaviour over an observation period...
16.
Kozer N, Clayton A
Eur Biophys J
. 2019 Nov;
49(1):21-37.
PMID: 31740999
The epidermal growth factor receptor (EGFR) is a membrane protein that regulates cell proliferation, differentiation and survival, and is a drug target for cancer therapy. Ligand-induced activation of the EGFR...
17.
Tran N, Shagaghi N, Clayton A
Methods Appl Fluoresc
. 2019 Oct;
8(1):014003.
PMID: 31622968
Biological proteins are understood in terms of five structural levels-primary, secondary, tertiary, quaternary and quinary. The quinary structure is defined as the set of macromolecular interactions that are transient in...
18.
Paviolo C, Chon J, Clayton A
Adv Exp Med Biol
. 2019 Jan;
1112:41-52.
PMID: 30637689
The epidermal growth factor receptor (EGFR) is an important cell surface receptor in normal physiology and disease. Recent work has shown that EGF-gold nanoparticle conjugates can influence cell behaviour, but...
19.
The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Zanetti-Domingues L, Korovesis D, Needham S, Tynan C, Sagawa S, Roberts S, et al.
Nat Commun
. 2018 Oct;
9(1):4325.
PMID: 30337523
Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and does not explain how mutations achieve ligand-independent...
20.
Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy
Parslow A, Clayton A, Lock P, Scott A
J Vis Exp
. 2018 Aug;
(138).
PMID: 30124657
Confocal microscopy provides an accessible methodology to capture sub-cellular interactions critical for the characterization and further development of pre-clinical agents labeled with fluorescent probes. With recent advancements in antibody based...