Andrew F Stewart
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Explore the profile of Andrew F Stewart including associated specialties, affiliations and a list of published articles.
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108
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3801
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Recent Articles
1.
Karakose E, Wang X, Wang P, Carcamo S, Demircioglu D, Lambertini L, et al.
Cell Rep Med
. 2024 Dec;
5(12):101832.
PMID: 39626675
Diabetes results from an inadequate number of insulin-producing human beta cells. There is currently no clinically available effective means to restore beta cell mass in millions of people with diabetes....
2.
Stewart A, Fulton S, Durand-de Cuttoli R, Thompson R, Chen P, Brindley E, et al.
bioRxiv
. 2024 Sep;
PMID: 39345578
Protein monoaminylation is a class of posttranslational modification (PTM) that contributes to transcription, physiology and behavior. While recent analyses have focused on histones as critical substrates of monoaminylation, the broader...
3.
Ables J, Israel L, Wood O, Govindarajulu U, Fremont R, Banerjee R, et al.
J Psychopharmacol
. 2024 Sep;
38(10):911-923.
PMID: 39301926
Background: Harmine is a component of the hallucinogenic brew, Ayahuasca, which also contains the psychoactive compound, , -dimethyltryptamine. Whether pharmaceutical-grade harmine hydrochloride (HCl) has psychoactive effects, the doses at which...
4.
Rosselot C, Li Y, Wang P, Alvarsson A, Beliard K, Lu G, et al.
Sci Transl Med
. 2024 Jul;
16(755):eadg3456.
PMID: 38985854
Five hundred thirty-seven million people globally suffer from diabetes. Insulin-producing β cells are reduced in number in most people with diabetes, but most individuals still have some residual β cells....
5.
Wang P, Wood O, Choleva L, Liu H, Karakose E, Lambertini L, et al.
bioRxiv
. 2024 May;
PMID: 38798411
The small molecule DYRK1A inhibitor, harmine, induces human beta cell proliferation, expands beta cell mass, enhances expression of beta cell phenotypic genes, and improves human beta cell function i and...
6.
Choleva L, Wang P, Liu H, Wood O, Lambertini L, Scott D, et al.
Endocrinology
. 2023 Dec;
165(2).
PMID: 38151968
Mutations in CDKN1C, encoding p57KIP2, a canonical cell cycle inhibitor, underlie multiple pediatric endocrine syndromes. Despite this central role in disease, little is known about the structure and function of...
7.
Katz L, Brill G, Wang P, Lambertini L, Zhang P, Haldeman J, et al.
Mol Metab
. 2023 Dec;
79:101848.
PMID: 38042369
Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose...
8.
Kang R, Lee J, Varela M, Li Y, Rosselot C, Zhang T, et al.
bioRxiv
. 2023 Nov;
PMID: 38014078
Prior studies have shown that pancreatic α-cells can transdifferentiate into β-cells, and that β-cells de-differentiate and are prone to acquire an α-cell phenotype in type 2 diabetes (T2D). However, the...
9.
Savic R, Yang J, Koplev S, An M, Patel P, OBrien R, et al.
Cell Rep
. 2023 Nov;
42(11):113371.
PMID: 37938972
Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we...
10.
Augustine M, Boudreau R, Cauley J, Majchel D, Nagaraj N, Roe L, et al.
Calcif Tissue Int
. 2023 Aug;
113(4):426-436.
PMID: 37640959
During lactation, changes in maternal calcium metabolism are necessary to provide adequate calcium for newborn skeletal development. The calcium in milk is derived from the maternal skeleton through a process...