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Andrew Eisen

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Articles 63
Citations 3103
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Recent Articles
1.
Eisen A, Kiernan M
Brain Sci . 2025 Feb; 15(2). PMID: 40002527
Most brain development occurs in the "first 1000 days", a critical period from conception to a child's second birthday. Critical brain processes that occur during this time include synaptogenesis, myelination,...
2.
Eisen A, Vucic S, Kiernan M
Muscle Nerve . 2024 Nov; 71(4):499-511. PMID: 39511939
Several decades have passed since the anterograde corticomotoneuronal hypothesis for amyotrophic lateral sclerosis (ALS) was proposed. The intervening years have witnessed its emergent support based on anatomical, pathological, physiological, neuroimaging,...
3.
Eisen A, Pioro E, Goutman S, Kiernan M
Brain Sci . 2024 May; 14(5). PMID: 38790450
Plastic production, which exceeds one million tons per year, is of global concern. The constituent low-density polymers enable spread over large distances and micro/nano particles (MNPLs) induce organ toxicity via...
4.
Eisen A, Nedergaard M, Gray E, Kiernan M
Prog Neurobiol . 2024 Jan; 234:102571. PMID: 38266701
The glymphatic system and the meningeal lymphatic vessels provide a pathway for transport of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is...
5.
Eisen A, Vucic S, Mitsumoto H
Clin Neurophysiol Pract . 2024 Jan; 9:1-12. PMID: 38213309
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder of the human motor system, first described in the 19th Century. The etiology of ALS appears to be multifactorial, with...
6.
Henderson R, Planeta Kepp K, Eisen A
Front Neurol . 2022 Jun; 13:890203. PMID: 35711269
Amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are neurodegenerations with evolutionary underpinnings, expansive clinical presentations, and multiple genetic risk factors involving a complex network of pathways. This perspective considers the...
7.
Greenberg B, Bowen J, Alvarez E, Rodriguez M, Caggiano A, Warrington A, et al.
Mult Scler J Exp Transl Clin . 2022 May; 8(2):20552173221091475. PMID: 35496758
Background: Recombinant human immunoglobulin M22 (rHIgM22) has promoted remyelination in animal models and was well tolerated in people with clinically stable multiple sclerosis. Objective: Safety/tolerability of a single rHIgM22 dose...
8.
Wu J, Tam M, Buch K, Khairati F, Wilson L, Bannerman E, et al.
BMC Palliat Care . 2022 Mar; 21(1):26. PMID: 35227242
Background: Respite care provides caregiving support to people with amyotrophic lateral sclerosis (ALS) and their care partners by providing the care partner with temporary relief from their caregiving duties. The...
9.
Eisen A, Bede P
Brain Behav . 2021 Oct; 11(12):e2403. PMID: 34710283
Background: Split phenotypes, (split hand, elbow, leg, and foot), are probably unique to ALS, and are characterized by having a shared peripheral input of both affected and unaffected muscles. This...
10.
Eisen A, Lemon R
Neurosci Lett . 2021 Aug; 762:136171. PMID: 34391870
Customarily the motor deficits that develop in ALS are considered in terms of muscle weakness. Functional rating scales used to assess ALS in terms of functional decline do not measure...