Andrew Eatherton
Overview
Explore the profile of Andrew Eatherton including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
41
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0
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Recent Articles
1.
Pike K, Hunt T, Barlaam B, Benstead D, Cadogan E, Chen K, et al.
J Med Chem
. 2024 Feb;
67(4):3090-3111.
PMID: 38306388
The inhibition of ataxia-telangiectasia mutated (ATM) has been shown to chemo- and radio-sensitize human glioma cells in vitro and therefore might provide an exciting new paradigm in the treatment of...
2.
Kettle J, Bagal S, Barratt D, Bodnarchuk M, Boyd S, Braybrooke E, et al.
J Med Chem
. 2023 Jul;
66(13):9147-9160.
PMID: 37395055
The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based...
3.
Kettle J, Bagal S, Bickerton S, Bodnarchuk M, Boyd S, Breed J, et al.
J Med Chem
. 2022 Apr;
65(9):6940-6952.
PMID: 35471939
KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now rendered this important GTPase druggable. Herein,...
4.
Kettle J, Bagal S, Bickerton S, Bodnarchuk M, Breed J, Carbajo R, et al.
J Med Chem
. 2020 Feb;
63(9):4468-4483.
PMID: 32023060
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS mutant represents an "Achilles heel" and has recently...
5.
Huang Y, Li T, Eatherton A, Mitchell W, Rong N, Ye L, et al.
Neuropharmacology
. 2013 Mar;
70:278-86.
PMID: 23485401
Accumulation of amyloid β (Aβ) in brain is a pathological hallmark of Alzheimer's disease (AD). Aβ is generated after sequential cleavage of its parental molecule, amyloid precursor protein (APP), by...
6.
Wan Z, Hall A, Jin Y, Xiang J, Yang E, Eatherton A, et al.
Bioorg Med Chem Lett
. 2011 Jun;
21(13):4016-9.
PMID: 21636276
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease...