Andrew D Nash
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Explore the profile of Andrew D Nash including associated specialties, affiliations and a list of published articles.
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20
Citations
690
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Recent Articles
1.
Drulyte I, Ghai R, Ow S, Kapp E, Quek A, Panousis C, et al.
Structure
. 2024 Jul;
32(10):1705-1710.e3.
PMID: 39059382
Activated FXII (FXIIa) is the principal initiator of the plasma contact system and can activate both procoagulant and proinflammatory pathways. Its activity is important in the pathophysiology of hereditary angioedema...
2.
Ow S, Kapp E, Tomasetig V, Zalewski A, Simmonds J, Panousis C, et al.
MAbs
. 2023 Jan;
15(1):2163459.
PMID: 36628468
Hageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for the prophylactic treatment of hereditary angioedema (HAE). CSL312 (garadacimab) is a novel high-affinity...
3.
Rigau M, Ostrouska S, Fulford T, Johnson D, Woods K, Ruan Z, et al.
Science
. 2020 Jan;
367(6478).
PMID: 31919129
Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2 T cell receptors (TCRs) that respond to phosphoantigens (pAgs) produced by cellular...
4.
Oon S, Monaghan K, Ng M, Hoi A, Morand E, Vairo G, et al.
Clin Transl Immunology
. 2020 Jan;
8(12):e01097.
PMID: 31890206
Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are major contributors to systemic lupus erythematosus (SLE) pathogenesis. IL-3 promotes pDC survival, but...
5.
Yip K, Wilson N, Pant H, Brown C, Busfield S, Ng M, et al.
Allergy
. 2019 Sep;
75(2):475-478.
PMID: 31505024
No abstract available.
6.
Hercus T, Kan W, Broughton S, Tvorogov D, Ramshaw H, Sandow J, et al.
Cold Spring Harb Perspect Biol
. 2017 Jul;
10(6).
PMID: 28716883
The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is...
7.
Irani Y, Scotney P, Klebe S, Mortimer L, Nash A, Williams K
Invest Ophthalmol Vis Sci
. 2017 Jul;
58(9):3404-3413.
PMID: 28692735
Purpose: We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regress nascent and established corneal blood vessels in the rat. Methods: A...
8.
Campbell I, Leong D, Edwards K, Rayzman V, Ng M, Goldberg G, et al.
J Immunol
. 2016 Nov;
197(11):4392-4402.
PMID: 27807194
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. G-CSF- and G-CSF receptor-deficient mice are profoundly...
9.
Oon S, Huynh H, Tai T, Ng M, Monaghan K, Biondo M, et al.
JCI Insight
. 2016 Oct;
1(6):e86131.
PMID: 27699260
To date, the major target of biologic therapeutics in systemic lupus erythematosus (SLE) has been the B cell, which produces pathogenic autoantibodies. Recently, targeting type I IFN, which is elaborated...
10.
Panousis C, Dhagat U, Edwards K, Rayzman V, Hardy M, Braley H, et al.
MAbs
. 2015 Dec;
8(3):436-53.
PMID: 26651396
The β common-signaling cytokines interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF) and IL-5 stimulate pro-inflammatory activities of haematopoietic cells via a receptor complex incorporating cytokine-specific α and shared β common...