Andrew D Morley
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Explore the profile of Andrew D Morley including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
152
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Recent Articles
11.
Asaad N, Bethel P, Coulson M, Dawson J, Ford S, Gerhardt S, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(15):4280-3.
PMID: 19515558
A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a...
12.
Morley A, Kenny P, Burton B, Heald R, MacFaul P, Mullett J, et al.
Bioorg Med Chem Lett
. 2009 Feb;
19(6):1658-61.
PMID: 19231183
A series of pyrimidine nitrile inhibitors of Cathepsin K with reduced glutathione reactivity has been identified and Molecular Core Matching (MoCoM) has been used to quantify the effect of an...
13.
MacFaul P, Morley A, Crawford J
Bioorg Med Chem Lett
. 2009 Jan;
19(4):1136-8.
PMID: 19168354
A quantitative assay involving the reaction of nitriles with glutathione and cysteine has been used as a simple in vitro screen to assess potential toxicity risk of candidate compounds in...
14.
Whittamore P, Addie M, Bennett S, Birch A, Butters M, Godfrey L, et al.
Bioorg Med Chem Lett
. 2006 Sep;
16(21):5567-71.
PMID: 16945526
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been...
15.
Black E, Breed J, Breeze A, Embrey K, Garcia R, Gero T, et al.
Bioorg Med Chem Lett
. 2005 May;
15(10):2503-7.
PMID: 15863305
Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.