Andrew D Hughes
Overview
Explore the profile of Andrew D Hughes including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
508
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Recent Articles
1.
Hughes A, Polonen P, Teachey D
Haematologica
. 2025 Jan;
PMID: 39781622
While outcomes for pediatric acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) have improved dramatically in recent decades, relapsed and refractory disease remain a significant therapeutic challenge. This is particularly...
2.
Hughes A, Teachey D, Diorio C
Semin Immunopathol
. 2024 Jul;
46(3-4):5.
PMID: 39012374
The advent of chimeric antigen receptor T cells (CAR-T) has been a paradigm shift in cancer immunotherapeutics, with remarkable outcomes reported for a growing catalog of malignancies. While CAR-T are...
3.
Li J, Hughes A, Kalantar T, Drake I, Tucker C, Moore J
ACS Macro Lett
. 2022 May;
3(10):976-980.
PMID: 35610803
Efficient encapsulation of tetraethylenepentamine (TEPA), as an example aliphatic amine, was achieved by an emulsion-templated, in situ polymerization. Hydrophobically modified clay nanoplatelets were employed as emulsifiers to obtain water-in-oil (W/O)...
4.
Hughes A, Kurre P
Br J Haematol
. 2021 Jul;
196(2):274-287.
PMID: 34258754
Recent advances have facilitated studies of the clonal architecture of the aging haematopoietic system, and provided clues to the mechanisms underlying the origins of hematopoietic malignancy. Much less is known...
5.
Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, et al.
J Clin Invest
. 2019 Nov;
130(1):287-294.
PMID: 31763998
Activation of host T cells that mediate allograft rejection is a 2-step process. The first occurs in secondary lymphoid organs where T cells encounter alloantigens presented by host DCs and...
6.
Hughes A, Lakkis F, Oberbarnscheidt M
J Am Soc Nephrol
. 2018 Apr;
29(6):1596-1600.
PMID: 29654214
Kidney transplantation is the treatment of choice for ESRD but is complicated by the response of the recipient's immune system to nonself histocompatibility antigens on the graft, resulting in rejection....
7.
Anderson K, de Guillebon A, Hughes A, Wang W, King M
Math Biosci
. 2017 Oct;
294:181-194.
PMID: 29024748
Selectin-mediated adhesion of circulating tumor cells (CTCs) to the endothelium is a critical step in cancer metastasis, a major factor contributing to the mortality of cancer. The formation of tethers...
8.
Zhuang Q, Liu Q, Divito S, Zeng Q, Yatim K, Hughes A, et al.
Nat Commun
. 2016 Aug;
7:12623.
PMID: 27554168
Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult,...
9.
Hughes A, Marsh G, Waugh R, Foster D, King M
Langmuir
. 2015 Nov;
31(50):13553-60.
PMID: 26605493
The nanoscale topography of adhesive surfaces is known to be an important factor governing cellular behavior. Previous work has shown that surface coatings composed of halloysite nanotubes enhance the adhesion,...
10.
Hedges E, Hughes A, Liesveld J, King M
Int J Mol Sci
. 2014 Aug;
15(9):15061-72.
PMID: 25167133
The α-chemokine, stromal-derived factor-1 (SDF-1), has been linked to the homing of circulating tumor cells to bone. SDF-1 is expressed by bone microvascular cells and osteoblasts and normally functions to...