Andrew Craxton
Overview
Explore the profile of Andrew Craxton including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
380
Followers
0
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Recent Articles
1.
Buckley N, Craxton A, Sun X, Panatta E, Pinon L, Beier S, et al.
Cell Death Dis
. 2024 Nov;
15(11):807.
PMID: 39516459
Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics....
2.
Mannion J, Gifford V, Bellenie B, Fernando W, Garcia L, Wilson R, et al.
Immunity
. 2024 May;
57(7):1514-1532.e15.
PMID: 38788712
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD). Although the catalytic function of RIPK1 is required to...
3.
Martinez Lagunas K, Savcigil D, Zrilic M, Carvajal Fraile C, Craxton A, Self E, et al.
Sci Adv
. 2023 Jul;
9(30):eadg2829.
PMID: 37494451
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is...
4.
Yam-Puc J, Hosseini Z, Horner E, Pereyra Gerber P, Beristain-Covarrubias N, Hughes R, et al.
Nat Commun
. 2023 Jun;
14(1):3292.
PMID: 37369658
Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here,...
5.
Chernova T, Grosso S, Sun X, Tenor A, Cabeza J, Craxton A, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293328
Malignant mesothelioma is an aggressive tumour of the pleura (MPM) or peritoneum with a clinical presentation at an advanced stage of the disease. Current therapies only marginally improve survival and...
6.
Craxton A, Munnur D, Jukes-Jones R, Skalka G, Langlais C, Cain K, et al.
Nat Commun
. 2018 Sep;
9(1):3877.
PMID: 30250067
PAXX is a recently identified component of the nonhomologous end joining (NHEJ) DNA repair pathway. The molecular mechanisms of PAXX action remain largely unclear. Here we characterise the interactomes of...
7.
Richards S, Watanabe C, Santos L, Craxton A, Clark E
Immunol Rev
. 2008 Sep;
224:183-200.
PMID: 18759927
B cells are induced to enter the cell cycle by stimuli including ligation of the B-cell receptor (BCR) complex and Toll-like receptor (TLR) agonists. This review discusses the contribution of...
8.
Craxton A, Draves K, Clark E
Eur J Immunol
. 2007 Aug;
37(10):2715-22.
PMID: 17705137
BH3-only Bcl-2 homologs are key regulators of the intrinsic apoptotic pathway. In particular, Bim, is critical for mediating apoptosis of hematopoietic cells including B cells. While studies using Bcl-2 Tg...
9.
Acosta-Rodriguez E, Craxton A, Hendricks D, Merino M, Montes C, Clark E, et al.
Eur J Immunol
. 2007 Mar;
37(4):990-1000.
PMID: 17357108
Microorganisms with pathogen-associated molecular patterns (PAMP) activate B cells directly by binding to TLR and also indirectly by inducing APC to release cytokines such as BAFF that promote B cell...
10.
Kohlhaas S, Craxton A, Sun X, Pinkoski M, Cohen G
J Biol Chem
. 2007 Mar;
282(17):12831-41.
PMID: 17327223
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is selectively toxic to tumor compared with normal cells. Other members of the TNF family of death ligands (TNF, CD95L) engage their respective...