Andrew Bassett
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Explore the profile of Andrew Bassett including associated specialties, affiliations and a list of published articles.
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35
Citations
1589
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Recent Articles
1.
Coelho M, Strauss M, Watterson A, Cooper S, Bhosle S, Illuzzi G, et al.
Nat Genet
. 2024 Oct;
56(11):2479-2492.
PMID: 39424923
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers...
2.
McLaren P, Porreca I, Iaconis G, Mok H, Mukhopadhyay S, Karakoc E, et al.
Nature
. 2023 Sep;
621(7979):E42.
PMID: 37670157
No abstract available.
3.
McLaren P, Porreca I, Iaconis G, Mok H, Mukhopadhyay S, Karakoc E, et al.
Nature
. 2023 Aug;
620(7976):1025-1030.
PMID: 37532928
HIV-1 remains a global health crisis, highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa, we assessed...
4.
Cooper S, Schwartzentruber J, Coomber E, Wu Q, Bassett A
Nucleic Acids Res
. 2023 May;
51(11):e64.
PMID: 37125635
Understanding the effects of genetic variation in gene regulatory elements is crucial to interpreting genome function. This is particularly pertinent for the hundreds of thousands of disease-associated variants identified by...
5.
Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, et al.
Mol Cell
. 2023 Mar;
83(7):1125-1139.e8.
PMID: 36917981
CRISPR activation (CRISPRa) is an important tool to perturb transcription, but its effectiveness varies between target genes. We employ human pluripotent stem cells with thousands of randomly integrated barcoded reporters...
6.
Coelho M, Cooper S, Strauss M, Karakoc E, Bhosle S, Goncalves E, et al.
Cancer Cell
. 2023 Jan;
41(2):288-303.e6.
PMID: 36669486
Interferon-γ (IFN-γ) signaling mediates host responses to infection, inflammation and anti-tumor immunity. Mutations in the IFN-γ signaling pathway cause immunological disorders, hematological malignancies, and resistance to immune checkpoint blockade (ICB)...
7.
Alsinet C, Primo M, Lorenzi V, Bello E, Kelava I, Jones C, et al.
Nat Commun
. 2022 May;
13(1):2885.
PMID: 35610203
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis protocols is imperative for their use in research, immunotherapies, and understanding human myelopoiesis. Here, we generate a >470K...
8.
Pribylova A, Fischer L, Pyott D, Bassett A, Molnar A
New Phytol
. 2022 May;
235(6):2285-2299.
PMID: 35524464
The impact of epigenetic modifications on the efficacy of CRISPR/Cas9-mediated double-stranded DNA breaks and subsequent DNA repair is poorly understood, especially in plants. In this study, we investigated the effect...
9.
Wassing I, Graham E, Saayman X, Rampazzo L, Ralf C, Bassett A, et al.
Nat Commun
. 2021 Sep;
12(1):5380.
PMID: 34508092
The RAD51 recombinase plays critical roles in safeguarding genome integrity, which is fundamentally important for all living cells. While interphase functions of RAD51 in maintaining genome stability are well-characterised, its...
10.
Carobbio S, Guenantin A, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, et al.
Stem Cell Reports
. 2021 Apr;
16(4):1010.
PMID: 33852883
No abstract available.