Andrew B Lassar
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Explore the profile of Andrew B Lassar including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Almubarak A, Zhang Q, Zhang C, Abdelwahab N, Kume T, Lassar A, et al.
Development
. 2024 Jul;
151(16).
PMID: 39012257
The Forkhead box transcription factors FOXC1 and FOXC2 are expressed in condensing mesenchyme cells at the onset of endochondral ossification. We used the Prx1-cre mouse to ablate Foxc1 and Foxc2...
2.
Almubarak A, Zhang Q, Zhang C, Lassar A, Kume T, Berry F
bioRxiv
. 2023 May;
PMID: 37162896
The forkhead box transcription factor genes and are expressed in the condensing mesenchyme of the developing skeleton prior to the onset of chondrocyte differentiation. To determine the roles of these...
3.
Zhang C, Gao Y, Hung H, Zhuo Z, Grodzinsky A, Lassar A
Nat Commun
. 2022 Nov;
13(1):7295.
PMID: 36435829
While prior work has established that articular cartilage arises from Prg4-expressing perichondrial cells, it is not clear how this process is specifically restricted to the perichondrium of synovial joints. We...
4.
Bell N, Bhagat S, Muruganandan S, Kim R, Ho K, Pierce R, et al.
Bone
. 2022 Apr;
160:116418.
PMID: 35398294
We previously found that FoxA factors are necessary for chondrocyte differentiation. To investigate whether FoxA factors alone are sufficient to drive chondrocyte hypertrophy, we build a FoxA2 transgenic mouse in...
5.
Zhang C, Gao Y, Jadhav U, Hung H, Holton K, Grodzinsky A, et al.
Commun Biol
. 2021 Mar;
4(1):332.
PMID: 33712729
A hallmark of cells comprising the superficial zone of articular cartilage is their expression of lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the development...
6.
Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao T, et al.
JCI Insight
. 2019 Mar;
4(5).
PMID: 30843886
During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy....
7.
Lassar A
Semin Cell Dev Biol
. 2017 Nov;
72:3-9.
PMID: 29097153
In 1987, Robert Davis, Hal Weintraub and I reported the identification of MyoD, a transcription factor that could reprogram fibroblasts into skeletal muscle cells. In this recollection, I both summarize...
8.
Li L, Newton P, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, et al.
FASEB J
. 2016 Dec;
31(3):1067-1084.
PMID: 27965322
Articular cartilage has little regenerative capacity. Recently, genetic lineage tracing experiments have revealed chondrocyte progenitors at the articular surface. We further characterized these progenitors by using genetic approaches. Histone H2B-green...
9.
Kozhemyakina E, Lassar A, Zelzer E
Development
. 2015 Feb;
142(5):817-31.
PMID: 25715393
Decades of work have identified the signaling pathways that regulate the differentiation of chondrocytes during bone formation, from their initial induction from mesenchymal progenitor cells to their terminal maturation into...
10.
Kozhemyakina E, Zhang M, Ionescu A, Ayturk U, Ono N, Kobayashi A, et al.
Arthritis Rheumatol
. 2015 Jan;
67(5):1261-73.
PMID: 25603997
Objective: To generate knockin mice that express a tamoxifen-inducible Cre recombinase from the Prg4 locus (Prg4(GFPCreERt2) mice) and to use these animals to fate-map the progeny of Prg4-positive articular cartilage...