Andrew A Gibb
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Explore the profile of Andrew A Gibb including associated specialties, affiliations and a list of published articles.
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27
Citations
1089
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Recent Articles
1.
Gibb A, LaPenna K, Gaspar R, Latchman N, Tan Y, Choya-Foces C, et al.
bioRxiv
. 2024 Nov;
PMID: 39484400
Background: Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of HF cases, with no effective treatments. The ZSF1-obese rat model recapitulates numerous clinical features of HFpEF including hypertension,...
2.
Joladarashi D, Thej C, Mallaredy V, Magadum A, Cimini M, Gonzalez C, et al.
iScience
. 2024 Oct;
27(10):111021.
PMID: 39429777
Mesenchymal stromal cells (MSC) are promising stem cell therapy for treating cardiovascular and other degenerative diseases. Diabetes affects the functional capability of MSC and impedes cell-based therapy. Despite numerous studies,...
3.
Lazaropoulos M, Gibb A, Chapski D, Nair A, Reiter A, Roy R, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(7):869-882.
PMID: 39196175
Differentiation of cardiac fibroblasts to myofibroblasts is necessary for matrix remodeling and fibrosis in heart failure. We previously reported that mitochondrial calcium signaling drives α-ketoglutarate-dependent histone demethylation, promoting myofibroblast formation....
4.
Demetriadou C, Gibb A, Elrod J, Snyder N
Nat Cardiovasc Res
. 2024 Aug;
2(12):1109-1111.
PMID: 39188987
The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin...
5.
Sharma R, Gibb A, Barnts K, Elrod J, Puri S
Microbiol Spectr
. 2023 Nov;
11(6):e0215723.
PMID: 37929974
The yeast exhibits metabolic flexibility for adaptability to host niches with varying availability of nutrients including essential metals like iron. For example, blood is iron deplete, while the oral cavity...
6.
Zheng Y, Gibb A, Xu H, Liu S, Hill B
Redox Biol
. 2023 May;
63:102740.
PMID: 37210780
Mitochondrial supercomplexes are observed in mammalian tissues with high energy demand and may influence metabolism and redox signaling. Nevertheless, the mechanisms that regulate supercomplex abundance remain unclear. In this study,...
7.
Gibb A, Huynh A, Gaspar R, Ploesch T, Lombardi A, Lorkiewicz P, et al.
J Mol Cell Cardiol
. 2022 Aug;
172:78-89.
PMID: 35988357
Background: Fibrosis and extracellular matrix remodeling are mediated by resident cardiac fibroblasts (CFs). In response to injury, fibroblasts activate, differentiating into specialized synthetic and contractile myofibroblasts producing copious extracellular matrix...
8.
Gibb A, Murray E, Huynh A, Gaspar R, Ploesch T, Bedi K, et al.
Circulation
. 2022 May;
145(21):1625-1628.
PMID: 35605036
No abstract available.
9.
Gibb A, Murray E, Eaton D, Huynh A, Tomar D, Garbincius J, et al.
JACC Basic Transl Sci
. 2021 Sep;
6(8):650-672.
PMID: 34466752
In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic...
10.
Gross P, Johnson J, Romero C, Eaton D, Poulet C, Sanchez-Alonso J, et al.
Circ Res
. 2020 Oct;
128(1):92-114.
PMID: 33092464
Rationale: Ca-induced Ca release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum....