Andreu Viader
Overview
Explore the profile of Andreu Viader including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
741
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0
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Recent Articles
1.
Wobst H, Viader A, Muncipinto G, Hollibaugh R, van Kalken D, Burkhart C, et al.
JCI Insight
. 2024 Nov;
9(21).
PMID: 39513367
BACKGROUNDThe toxic accumulation of phenylalanine (Phe) in the brain underlies the neurological presentation of phenylketonuria (PKU). Solute carrier family 6 member 19 (SLC6A19) is the major transporter responsible for the...
2.
Daou N, Viader A, Cokol M, Nitzel A, Chakravarthy M, Afeyan R, et al.
Sci Rep
. 2021 Jun;
11(1):11861.
PMID: 34088912
Nonalcoholic steatohepatitis (NASH) is a complex metabolic disease of heterogeneous and multifactorial pathogenesis that may benefit from coordinated multitargeted interventions. Endogenous metabolic modulators (EMMs) encompass a broad set of molecular...
3.
Clapper J, Henry C, Niphakis M, Knize A, Coppola A, Simon G, et al.
J Pharmacol Exp Ther
. 2018 Oct;
367(3):494-508.
PMID: 30305428
Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). The first MGLL inhibitors have recently entered clinical development for the treatment of neurologic disorders. To support...
4.
Liu X, Chen Y, Vickstrom C, Li Y, Viader A, Cravatt B, et al.
Sci Rep
. 2016 Oct;
6:35829.
PMID: 27775008
The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates retrograde synaptic depression including depolarization-induced suppression of excitation (DSE) and inhibition (DSI). 2-AG is degraded primarily by monoacylglycerol lipase (MAGL), which is expressed in neurons...
5.
Chen Y, Liu X, Vickstrom C, Liu M, Zhao L, Viader A, et al.
eNeuro
. 2016 May;
3(3).
PMID: 27182552
Endocannabinoids are diffusible lipophilic molecules that may spread to neighboring synapses. Monoacylglycerol lipase (MAGL) is the principal enzyme that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG). Using knock-out mice in which MAGL...
6.
Viader A, Ogasawara D, Joslyn C, Sanchez-Alavez M, Mori S, Nguyen W, et al.
Elife
. 2016 Jan;
5:e12345.
PMID: 26779719
Metabolic specialization among major brain cell types is central to nervous system function and determined in large part by the cellular distribution of enzymes. Serine hydrolases are a diverse enzyme...
7.
Ogasawara D, Deng H, Viader A, Baggelaar M, Breman A, den Dulk H, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
113(1):26-33.
PMID: 26668358
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes...
8.
Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura D, et al.
PLoS One
. 2015 Aug;
10(8):e0134437.
PMID: 26287872
Cyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE2). Historically, phospholipases have been considered...
9.
Viader A, Blankman J, Zhong P, Liu X, Schlosburg J, Joslyn C, et al.
Cell Rep
. 2015 Jul;
12(5):798-808.
PMID: 26212325
The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG signaling is terminated by enzymatic hydrolysis-a reaction that is principally performed by monoacylglycerol...
10.
Inloes J, Hsu K, Dix M, Viader A, Masuda K, Takei T, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(41):14924-9.
PMID: 25267624
Complex hereditary spastic paraplegia (HSP) is a genetic disorder that causes lower limb spasticity and weakness and intellectual disability. Deleterious mutations in the poorly characterized serine hydrolase DDHD2 are a...