Andres D Klein
Overview
Explore the profile of Andres D Klein including associated specialties, affiliations and a list of published articles.
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32
Citations
656
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Recent Articles
1.
Klein A, Eden E, Zanlungo S
Trends Mol Med
. 2024 Dec;
31(2):195-196.
PMID: 39672736
No abstract available.
2.
Rubilar J, Outeiro T, Klein A
Brain
. 2024 Mar;
147(8):2610-2620.
PMID: 38437875
Parkinson's disease is a neurodegenerative disorder primarily known for typical motor features that arise due to the loss of dopaminergic neurons in the substantia nigra. However, the precise molecular aetiology...
3.
4.
Heras M, Szenfeld B, Ballout R, Buratti E, Zanlungo S, Dardis A, et al.
NPJ Genom Med
. 2023 Aug;
8(1):21.
PMID: 37567876
Niemann-Pick type C (NPC) disease is a lysosomal storage disease (LSD) characterized by the buildup of endo-lysosomal cholesterol and glycosphingolipids due to loss of function mutations in the NPC1 and...
5.
Duran A, Priestman D, Heras M, Rebolledo-Jaramillo B, Olguin V, Calderon J, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902345
Identification of genetic modulators of lysosomal enzyme activities and glycosphingolipids (GSLs) may facilitate the development of therapeutics for diseases in which they participate, including Lysosomal Storage Disorders (LSDs). To this...
6.
Olguin V, Duran A, Heras M, Rubilar J, Cubillos F, Olguin P, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886916
We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments...
7.
Duran A, Rebolledo-Jaramillo B, Olguin V, Rojas-Herrera M, Heras M, Calderon J, et al.
Biochem Biophys Rep
. 2021 Aug;
28:101105.
PMID: 34458595
The acid β-glucocerebrosidase (GCase) enzyme cleaves glucosylceramide into glucose and ceramide. Loss of function variants in the gene encoding for GCase can lead to Gaucher disease and Parkinson's disease. Therapeutic...
8.
Balboa E, Marin T, Oyarzun J, Contreras P, Hardt R, van den Bosch T, et al.
Cells
. 2021 Aug;
10(8).
PMID: 34440927
Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the gene. The most affected tissues are the central nervous system and liver, and while significant...
9.
Duhan V, Khairnar V, Kitanovski S, Hamdan T, Klein A, Lang J, et al.
Front Immunol
. 2021 Feb;
11:607889.
PMID: 33584680
Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be...
10.
Meneses-Salas E, Garcia-Forn M, Castany-Pladevall C, Lu A, Fajardo A, Jose J, et al.
Am J Pathol
. 2020 Dec;
191(3):475-486.
PMID: 33345999
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NPC disease primarily affects the brain, causing neuronal...