Andreas Mantoulidis
Overview
Explore the profile of Andreas Mantoulidis including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
340
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0
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Recent Articles
1.
Junk L, Schmiedel V, Guha S, Fischel K, Greb P, Vill K, et al.
Nat Commun
. 2024 Mar;
15(1):2005.
PMID: 38443338
Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance but be designed to slow down the emergence...
2.
Kim D, Herdeis L, Rudolph D, Zhao Y, Bottcher J, Vides A, et al.
Nature
. 2023 May;
619(7968):160-166.
PMID: 37258666
KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit its function have been continuing for decades. The most successful of these has been...
3.
Martinelli P, Schaaf O, Mantoulidis A, Martin L, Fuchs J, Bader G, et al.
ChemMedChem
. 2023 Jan;
18(6):e202200686.
PMID: 36649575
The bromodomain and PHD-finger containing transcription factor (BPTF) is part of the nucleosome remodeling factor (NURF) complex and has been implicated in multiple cancer types. Here, we report the discovery...
4.
Broker J, Waterson A, Smethurst C, Kessler D, Bottcher J, Mayer M, et al.
J Med Chem
. 2022 Oct;
65(21):14614-14629.
PMID: 36300829
Activating mutations in KRAS are the most frequent oncogenic alterations in cancer. The oncogenic hotspot position 12, located at the lip of the switch II pocket, offers a covalent attachment...
5.
Kessler D, Gollner A, Gmachl M, Mantoulidis A, Martin L, Zoephel A, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(7):3365-3367.
PMID: 32047042
No abstract available.
6.
Kessler D, Gmachl M, Mantoulidis A, Martin L, Zoephel A, Mayer M, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(32):15823-15829.
PMID: 31332011
The 3 human RAS genes, KRAS, NRAS, and HRAS, encode 4 different RAS proteins which belong to the protein family of small GTPases that function as binary molecular switches involved...
7.
Bergner A, Cockcroft X, Fischer G, Gollner A, Hela W, Kousek R, et al.
Chemistry
. 2019 Jun;
25(52):12037-12041.
PMID: 31231840
Natural products have proven to be a rich source of molecular architectures for drugs. Here, an integrated approach to natural product screening is proposed, which uncovered eight new natural product...