Andreas Leffler
Overview
Explore the profile of Andreas Leffler including associated specialties, affiliations and a list of published articles.
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Articles
100
Citations
1976
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Recent Articles
1.
Rocereta J, Sturhahn T, Pumroy R, Fricke T, Herzog C, Leffler A, et al.
Nat Struct Mol Biol
. 2025 Feb;
PMID: 39972168
The transient receptor potential vanilloid 2 (TRPV2) cation channel is a key player in cardiovascular physiology and pathophysiology. Probenecid (PBC), an FDA-approved uricosuric agent thought to activate TRPV2, has shown...
2.
Fricke T, Leffler A
J Physiol Sci
. 2024 Sep;
74(1):42.
PMID: 39285320
Transient receptor potential (TRP) ion channels serve as sensors for variations in ambient temperature, modulating both thermoregulation and temperature responsive cellular processes. Among these, the vanilloid TRP subfamily (TRPV) comprises...
3.
Kriedemann N, Manstein F, Hernandez-Bautista C, Ullmann K, Triebert W, Franke A, et al.
Stem Cell Res Ther
. 2024 Jul;
15(1):213.
PMID: 39020441
Background: Commonly used media for the differentiation of human pluripotent stem cells into cardiomyocytes (hPSC-CMs) contain high concentrations of proteins, in particular albumin, which is prone to quality variations and...
4.
Schneider A, Hage A, Stein I, Kriedemann N, Zweigerdt R, Leffler A
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928302
An accumulation of reactive oxygen species (ROS) in cardiomyocytes can induce pro-arrhythmogenic late Na currents by removing the inactivation of voltage-gated Na channels including the tetrodotoxin (TTX)-resistant cardiac α-subunit Nav1.5...
5.
Bolesani E, Bornhorst D, Iyer L, Zawada D, Friese N, Morgan M, et al.
Cardiovasc Res
. 2024 Jun;
120(11):1295-1311.
PMID: 38836637
Aims: Understanding the molecular identity of human pluripotent stem cell (hPSC)-derived cardiac progenitors and mechanisms controlling their proliferation and differentiation is valuable for developmental biology and regenerative medicine. Methods And...
6.
Gallo P, Mihelc E, Eisert R, Bradshaw G, Dimek F, Leffler A, et al.
Cell Calcium
. 2024 May;
121:102894.
PMID: 38728789
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2's physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways...
7.
Haug F, Pumroy R, Sridhar A, Pantke S, Dimek F, Fricke T, et al.
EMBO J
. 2024 Apr;
43(11):2264-2290.
PMID: 38671253
Transient receptor potential (TRP) ion channels are involved in the surveillance or regulation of the acid-base balance. Here, we demonstrate that weak carbonic acids, including acetic acid, lactic acid, and...
8.
Schiessler J, Leffler A
Anaesthesiologie
. 2024 Apr;
73(4):223-231.
PMID: 38568253
The limitations and disadvantages of opioids in anesthesia are very well known but the advantages combined with a lack of effective alternatives even now still prevents refraining from using opioids...
9.
Pumroy R, De Jesus-Perez J, Protopopova A, Rocereta J, Fluck E, Fricke T, et al.
EMBO Rep
. 2024 Jan;
25(2):506-523.
PMID: 38225355
Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal...
10.
Greite R, Schott S, Wang L, Gohlke L, Kreimann K, Derlin K, et al.
Clin Transl Sci
. 2023 Oct;
16(12):2729-2743.
PMID: 37899696
Free heme is released from hemoproteins during hemolysis or ischemia reperfusion injury and can be pro-inflammatory. Most studies on nephrotoxicity of hemolysis-derived proteins focus on free hemoglobin (fHb) with heme...