Andreas Brown
Overview
Explore the profile of Andreas Brown including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
141
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0
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Recent Articles
1.
Vogel M, Mohrle B, Sakk V, Brown A, Palmer A, Braumuller S, et al.
Shock
. 2022 Jun;
57(6):260-267.
PMID: 35759306
Thoracic trauma is a major cause of mortality due to the associated inflammatory acute respiratory distress syndrome and morbidity due to impaired tissue regeneration. Trauma-induced lung inflammation is characterized by...
2.
Huppertz S, Senger K, Brown A, Leins H, Eiwen K, Mulaw M, et al.
Exp Hematol
. 2021 Jun;
99:32-43.e13.
PMID: 34126175
Histone methylases and demethylases regulate gene expression programs in hematopoiesis. The molecular function of the demethylase KDM6A in normal hematopoiesis and, in particular, for the hematopoietic stem and progenitor cell...
3.
Vogel M, Moehrle B, Brown A, Eiwen K, Sakk V, Geiger H
Stem Cells
. 2019 Oct;
37(12):1606-1614.
PMID: 31574190
Adult hematopoietic stem cells (HSCs) maintain tissue homeostasis and regenerative capacity of the hematopoietic system through self-renewal and differentiation. Metabolism is recognized as an important regulatory entity controlling stem cells....
4.
Brown A, Schuetz D, Han Y, Daria D, Nattamai K, Eiwen K, et al.
Haematologica
. 2019 May;
105(2):317-324.
PMID: 31073078
No abstract available.
5.
Vogel M, Christow H, Manz I, Denkinger M, Amoah A, Schutz D, et al.
Shock
. 2018 Oct;
51(4):430-438.
PMID: 30289853
Endogenously mobilized stem and progenitor cells (SPCs) or exogenously provided SPCs are thought to be beneficial for trauma therapy. However, still little is known about the synchronized dynamics of the...
6.
Brown A, Geiger H
Cell Mol Life Sci
. 2018 Aug;
75(20):3771-3779.
PMID: 30066086
Loss of chromosome integrity is a major contributor to cancer. Checkpoints within the cell division cycle that facilitate the accuracy and outcome of chromosome segregation are thus critical pathways for...
7.
Brown A, Pospiech J, Eiwen K, Baker D, Moehrle B, Sakk V, et al.
Stem Cell Reports
. 2017 Oct;
9(5):1359-1368.
PMID: 29056333
The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells. While leukemia is frequently driven by transformed...
8.
Moehrle B, Nattamai K, Brown A, Florian M, Ryan M, Vogel M, et al.
Cell Rep
. 2015 Dec;
13(11):2412-2424.
PMID: 26686632
Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2- to 3-fold increase...
9.
Hellmuth S, Rata S, Brown A, Heidmann S, Novak B, Stemmann O
Mol Cell
. 2015 Apr;
58(3):495-506.
PMID: 25921067
Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit by separase triggers chromosome segregation in anaphase. Vertebrate separase is held inactive by mutually exclusive binding to securin...
10.
Hellmuth S, Pohlmann C, Brown A, Bottger F, Sprinzl M, Stemmann O
J Biol Chem
. 2015 Feb;
290(12):8002-10.
PMID: 25659430
Sister chromatid cohesion is established during replication by entrapment of both dsDNAs within the cohesin ring complex. It is dissolved in anaphase when separase, a giant cysteine endopeptidase, cleaves the...