Andreas Boettcher
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Explore the profile of Andreas Boettcher including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
301
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Recent Articles
1.
McManus R, Komes M, Griep A, Santarelli F, Schwartz S, Ramon Perea J, et al.
Immunity
. 2025 Feb;
58(2):326-343.e11.
PMID: 39904338
Activation of the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer's disease (AD) via the release of IL-1β and ASC specks. However, whether NLRP3 is involved in pathways...
2.
Mackay A, Velcicky J, Gommermann N, Mattes H, Janser P, Wright M, et al.
J Med Chem
. 2024 Nov;
67(23):20780-20798.
PMID: 39574318
Activation of the NLRP3 inflammasome in response to danger signals is a key innate immune mechanism and results in the production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18)...
3.
Vulpetti A, Rondeau J, Bellance M, Blank J, Boesch R, Boettcher A, et al.
J Med Chem
. 2024 May;
67(10):8141-8160.
PMID: 38728572
Human interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a critical role in the regulation of the immune response and the development of various inflammatory diseases. In this publication, we...
4.
Lin A, Bapat A, Xiao L, Niroula A, Ye J, Wong W, et al.
Circulation
. 2024 Feb;
149(18):1419-1434.
PMID: 38357791
Background: Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk...
5.
Velcicky J, Janser P, Gommermann N, Brenneisen S, Ilic S, Vangrevelinghe E, et al.
J Med Chem
. 2024 Jan;
67(2):1544-1562.
PMID: 38175811
NLRP3 is a molecular sensor recognizing a wide range of danger signals. Its activation leads to the assembly of an inflammasome that allows for activation of caspase-1 and subsequent maturation...
6.
Hommel U, Hurth K, Rondeau J, Vulpetti A, Ostermeier D, Boettcher A, et al.
Nat Commun
. 2023 Sep;
14(1):5497.
PMID: 37679328
Human interleukin-1β (hIL-1β) is a pro-inflammatory cytokine involved in many diseases. While hIL-1β directed antibodies have shown clinical benefit, an orally available low-molecular weight antagonist is still elusive, limiting the...
7.
Neuwirt E, Magnani G, Cikovic T, Wohrle S, Fischer L, Kostina A, et al.
Sci Signal
. 2023 Jan;
16(768):eabh1083.
PMID: 36649377
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We...
8.
Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, et al.
J Mol Biol
. 2021 Oct;
433(24):167309.
PMID: 34687713
The NLRP3 inflammasome assembles in response to a variety of pathogenic and sterile danger signals, resulting in the production of interleukin-1β and interleukin-18. NLRP3 is a key component of the...
9.
Unterreiner A, Rubert J, Kauffmann M, Fruhauf A, Heiser D, Erbel P, et al.
Biochem Biophys Res Commun
. 2021 Feb;
545:177-182.
PMID: 33561652
The NLRP3 inflammasome is a critical component of the innate immune response to sterile inflammation. Its regulation involves a priming step, required for up-regulation of inflammasome protagonists and an activation...
10.
Chen K, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady C, et al.
EMBO J
. 2019 Mar;
38(10).
PMID: 30902848
Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase-1, caspase-4, caspase-5 and caspase-11. These caspases cleave and activate the pore-forming protein gasdermin D (GSDMD) to induce...