Andrea Sturchio
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Explore the profile of Andrea Sturchio including associated specialties, affiliations and a list of published articles.
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44
Citations
559
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Recent Articles
1.
Espay A, Lees A, Cardoso F, Frucht S, Erskine D, Sandoval I, et al.
Parkinsonism Relat Disord
. 2025 Jan;
131():107256.
PMID: 39794217
The α-synuclein seed amplification assay (αSyn-SAA) sensitively detects Lewy pathology, the amyloid state of α-synuclein, in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD). The αSyn-SAA harnesses the...
2.
Christ W, Kapell S, Sobkowiak M, Mermelekas G, Evertsson B, Sork H, et al.
ACS Chem Neurosci
. 2024 Nov;
15(22):4095-4104.
PMID: 39510798
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed interest in the correlation between viral infections and neurodegenerative brain disorders....
3.
Lerche S, Wurster I, Valente E, Avenali M, Samaniego D, Martinez-Vicente M, et al.
NPJ Parkinsons Dis
. 2024 Oct;
10(1):198.
PMID: 39448669
Variants in GBA1 result in dysregulated sphingolipids. We investigated five CSF d18:1 sphingolipid species in a longitudinal multicenter cohort comprising people with Parkinson's Disease and Dementia with Lewy bodies with...
4.
Diaz-Holguin A, Saarinen M, Vo D, Sturchio A, Branzell N, Cabeza de Vaca I, et al.
Sci Adv
. 2024 Aug;
10(32):eadn1524.
PMID: 39110804
Artificial intelligence is revolutionizing protein structure prediction, providing unprecedented opportunities for drug design. To assess the potential impact on ligand discovery, we compared virtual screens using protein structures generated by...
5.
Appleton E, Khosousi S, Ta M, Nalls M, Singleton A, Sturchio A, et al.
Transl Neurodegener
. 2024 Jun;
13(1):31.
PMID: 38863007
No abstract available.
6.
Khosousi S, Sturchio A, Appleton E, Paslawski W, Ta M, Nalls M, et al.
Mov Disord
. 2024 May;
39(10):1881-1885.
PMID: 38798037
Background: Recent studies identified increased cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker for parkinsonian disorders, suggesting a compensation to dying dopaminergic neurons. A correlation with 123I-FP-CIT-SPECT (DaT-SPECT)...
7.
Sturchio A, Rocha E, Kauffman M, Marsili L, Mahajan A, Saraf A, et al.
Brain Sci
. 2024 Feb;
14(2).
PMID: 38391726
Animal models have been used to gain pathophysiologic insights into Parkinson's disease (PD) and aid in the translational efforts of interventions with therapeutic potential in human clinical trials. However, no...
8.
Ezzat K, Sturchio A, Espay A
Handb Clin Neurol
. 2023 Feb;
193:23-32.
PMID: 36803814
The toxic proteinopathy paradigm has defined neurodegenerative disorders for over a century. This gain-of-function (GOF) framework posited that proteins become toxic when turned into amyloids (pathology), predicting that lowering its...
9.
Sturchio A, Duker A, Munoz-Sanjuan I, Espay A
Handb Clin Neurol
. 2023 Feb;
193:171-184.
PMID: 36803810
Huntington disease is a highly disabling neurodegenerative disease characterized by psychiatric, cognitive, and motor deficits. The causal genetic mutation in huntingtin (Htt, also known as IT15), located on chromosome 4p16.3,...
10.
Pathology vs pathogenesis: Rationale and pitfalls in the clinicopathology model of neurodegeneration
Donadio V, Sturchio A, Rizzo G, Abu Rumeileh S, Liguori R, Espay A
Handb Clin Neurol
. 2023 Feb;
192:35-55.
PMID: 36796947
In neurodegenerative disorders, the term pathology is often implicitly referred to as pathogenesis. Pathology has been conceived as a window into the pathogenesis of neurodegenerative disorders. This clinicopathologic framework posits...