Andrea Schmidts
Overview
Explore the profile of Andrea Schmidts including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1427
Followers
0
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Recent Articles
1.
Frigault M, Graham C, Berger T, Ritchey J, Horick N, El-Jawahri A, et al.
Blood
. 2024 May;
144(11):1153-1167.
PMID: 38781564
We report a first-in-human clinical trial using chimeric antigen receptor (CAR) T cells targeting CD37, an antigen highly expressed in B- and T-cell malignancies. Five patients with relapsed or refractory...
2.
Ormhoj M, Scarfo I, Cabral M, Bailey S, Lorrey S, Bouffard A, et al.
Clin Cancer Res
. 2024 May;
30(10):2286.
PMID: 38745479
No abstract available.
3.
Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson R, et al.
Clin Cancer Res
. 2024 Feb;
30(9):1859-1877.
PMID: 38393682
Purpose: Targeting solid tumors with chimeric antigen receptor (CAR) T cells remains challenging due to heterogenous target antigen expression, antigen escape, and the immunosuppressive tumor microenvironment (TME). Pancreatic cancer is...
4.
Larson R, Kann M, Graham C, Mount C, Castano A, Lee W, et al.
Nat Commun
. 2023 Nov;
14(1):7509.
PMID: 37980341
Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions....
5.
Grunewald J, Schmidts A
Nat Biomed Eng
. 2023 May;
7(5):607-608.
PMID: 37208465
No abstract available.
6.
7.
Schmidts A, Srivastava A, Ramapriyan R, Bailey S, Bouffard A, Cahill D, et al.
Neurooncol Adv
. 2023 Feb;
5(1):vdac185.
PMID: 36751672
Background: Chimeric antigen receptor (CAR) T cells have achieved remarkable responses in patients with hematological malignancies; however, the potential of this therapeutic platform for solid tumors like glioblastoma (GBM) has...
8.
Leick M, Silva H, Scarfo I, Larson R, Choi B, Bouffard A, et al.
Cancer Cell
. 2022 Apr;
40(5):494-508.e5.
PMID: 35452603
Chimeric antigen receptor (CAR) T cell therapy is effective in lymphoid malignancies, but there has been limited data in myeloid cancers. Here, we start with a CD27-based CAR to target...
9.
Larson R, Kann M, Bailey S, Haradhvala N, Montero Llopis P, Bouffard A, et al.
Nature
. 2022 Apr;
604(7906):563-570.
PMID: 35418687
Chimeric antigen receptor (CAR) therapy has had a transformative effect on the treatment of haematologic malignancies, but it has shown limited efficacy against solid tumours. Solid tumours may have cell-intrinsic...
10.
Bailey S, Vatsa S, Larson R, Bouffard A, Scarfo I, Kann M, et al.
Blood Cancer Discov
. 2022 Jan;
3(2):136-153.
PMID: 35015685
Significance: Blocking IFNγ in CAR T cells does not impair their cytotoxicity against hematologic tumor cells and paradoxically enhances their proliferation and reduces macrophage-mediated cytokines and chemokines associated with CRS....