Andrea Scelfo
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Explore the profile of Andrea Scelfo including associated specialties, affiliations and a list of published articles.
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19
Citations
1060
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Recent Articles
1.
Herve S, Scelfo A, Bersano Marchisio G, Grison M, Vaidziulyte K, Dumont M, et al.
Nat Cell Biol
. 2025 Jan;
27(1):73-86.
PMID: 39779939
Errors during cell division lead to aneuploidy, which is associated with genomic instability and cell transformation. In response to aneuploidy, cells activate the tumour suppressor p53 to elicit a surveillance...
2.
Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, et al.
Nat Commun
. 2024 Apr;
15(1):2960.
PMID: 38580649
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance...
3.
Scelfo A, Barra V, Abdennur N, Spracklin G, Busato F, Salinas-Luypaert C, et al.
J Cell Biol
. 2024 Feb;
223(4).
PMID: 38376465
DNA methylation (DNAme) is a key epigenetic mark that regulates critical biological processes maintaining overall genome stability. Given its pleiotropic function, studies of DNAme dynamics are crucial, but currently available...
4.
Scelfo A, Angrisani A, Grillo M, Barnes B, Muyas F, Sauer C, et al.
Mol Cell
. 2024 Feb;
84(6):1003-1020.e10.
PMID: 38359824
The high incidence of whole-arm chromosome aneuploidy and translocations in tumors suggests instability of centromeres, unique loci built on repetitive sequences and essential for chromosome separation. The causes behind this...
5.
Scelfo A, Fachinetti D
DNA Repair (Amst)
. 2023 Sep;
130:103569.
PMID: 37708591
Centromeres play a key role in the maintenance of genome stability to prevent carcinogenesis and diseases. They are specialized chromosome loci essential to ensure faithful transmission of genomic information across...
6.
Giunta S, Herve S, White R, Wilhelm T, Dumont M, Scelfo A, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33653953
Chromosome segregation relies on centromeres, yet their repetitive DNA is often prone to aberrant rearrangements under pathological conditions. Factors that maintain centromere integrity to prevent centromere-associated chromosome translocations are unknown....
7.
Scelfo A, Fachinetti D
Cells
. 2019 Aug;
8(8).
PMID: 31426433
In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity. Centromeres play an essential task...
8.
Pivetti S, Fernandez-Perez D, dAmbrosio A, Barbieri C, Manganaro D, Rossi A, et al.
Sci Adv
. 2019 May;
5(5):eaav1594.
PMID: 31106267
Polycomb repressive complexes are evolutionarily conserved complexes that maintain transcriptional repression during development and differentiation to establish and preserve cell identity. We recently described the fundamental role of PRC1 in...
9.
Scelfo A, Fernandez-Perez D, Tamburri S, Zanotti M, Lavarone E, Soldi M, et al.
Mol Cell
. 2019 Apr;
74(5):1037-1052.e7.
PMID: 31029542
Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) control cell identity by establishing facultative heterochromatin repressive domains at common sets of target genes. PRC1, which deposits H2Aub1 through the...
10.
Barra V, Logsdon G, Scelfo A, Hoffmann S, Herve S, Aslanian A, et al.
Nat Commun
. 2019 Jan;
10(1):175.
PMID: 30635586
CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic centromeres via its CENP-A targeting domain and either one of its terminal regions. In humans, several...