Andrea R Di Sebastiano
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Explore the profile of Andrea R Di Sebastiano including associated specialties, affiliations and a list of published articles.
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9
Citations
132
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Recent Articles
1.
Di Sebastiano A, Deweyert A, Benoit S, Iredale E, Xu H, De Oliveira C, et al.
Sci Rep
. 2018 May;
8(1):7301.
PMID: 29740075
Glioblastoma (GBM) is the leading cause of high fatality cancer arising within the adult brain. Electrotherapeutic approaches offer new promise for GBM treatment by exploiting innate vulnerabilities of cancer cells...
2.
Di Sebastiano A, Fahim S, Dunn H, Walther C, Ribeiro F, Cregan S, et al.
J Biol Chem
. 2016 Jul;
291(34):17602-15.
PMID: 27358397
Activation of Group I metabotropic glutamate receptors (mGluRs) activates signaling cascades, resulting in calcium release from intracellular stores, ERK1/2 activation, and long term changes in synaptic activity that are implicated...
3.
Staudt M, Di Sebastiano A, Xu H, Jog M, Schmid S, Foster P, et al.
Gerontology
. 2015 Sep;
62(3):371-80.
PMID: 26330171
Parkinson's disease (PD) affects an estimated 7-10 million people worldwide and remains without definitive or disease-modifying treatment. There have been many recent developments in cell-based therapy (CBT) to replace lost...
4.
Raka F, Di Sebastiano A, Kulhawy S, Ribeiro F, Godin C, Caetano F, et al.
Mol Brain
. 2015 Apr;
8:21.
PMID: 25885040
Background: Agonist stimulation of Group I metabotropic glutamate receptors (mGluRs) initiates their coupling to the heterotrimeric G protein, Gαq/11, resulting in the activation of phospholipase C, the release of Ca(2+)...
5.
Di Sebastiano A, Coolen L
Prog Brain Res
. 2012 Jul;
198:65-77.
PMID: 22813970
Orexin, also known as hypocretin, is a hypothalamic neuropeptide important for mediation of arousal and sleep as well as feeding and energy homeostasis. Recent studies have indicated that orexin also...
6.
Pitchers K, Schmid S, Di Sebastiano A, Wang X, Laviolette S, Lehman M, et al.
PLoS One
. 2012 Apr;
7(4):e34700.
PMID: 22529926
Natural reward and drugs of abuse converge upon the mesolimbic system which mediates motivation and reward behaviors. Drugs induce neural adaptations in this system, including transcriptional, morphological, and synaptic changes,...
7.
Di Sebastiano A, Wilson-Perez H, Lehman M, Coolen L
Horm Behav
. 2010 Sep;
59(1):1-8.
PMID: 20851122
The hypothalamic neuropeptide orexin (hypocretin) mediates reward related to drugs of abuse and food intake. However, a role for orexin in sexual reward has yet to be investigated. Orexin neurons...
8.
Di Sebastiano A, Yong-Yow S, Wagner L, Lehman M, Coolen L
Horm Behav
. 2010 Jun;
58(3):397-404.
PMID: 20541554
The hypothalamic neuropeptide orexin mediates arousal, sleep, and naturally rewarding behaviors, including food intake. Male sexual behavior is altered by orexin receptor-1 agonists or antagonists, suggesting a role for orexin-A...
9.
Davis J, Loos M, Di Sebastiano A, Brown J, Lehman M, Coolen L
Biol Psychiatry
. 2010 Mar;
67(12):1199-204.
PMID: 20346444
Background: An inability to inhibit behaviors once they become maladaptive is a component of several psychiatric illnesses, and the medial prefrontal cortex (mPFC) was identified as a potential mediator of...