Andrea Pepper
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Explore the profile of Andrea Pepper including associated specialties, affiliations and a list of published articles.
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11
Citations
138
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Recent Articles
1.
Vareli A, Narayanan H, Clark H, Jayawant E, Zhou H, Liu Y, et al.
bioRxiv
. 2024 Dec;
PMID: 39677808
In Diffuse Large B-cell Lymphoma (DLBCL), elevated anti-apoptotic BCL2-family proteins (e.g., MCL1, BCL2, BCLXL) and NF-κB subunits (RelA, RelB, cRel) confer poor prognosis. Heterogeneous expression, regulatory complexity, and redundancy offsetting...
2.
Norris R, Jones J, Mancini E, Chevassut T, Simoes F, Pepper C, et al.
Blood Cancer J
. 2024 Jul;
14(1):105.
PMID: 38965209
Genetic heterogeneity and co-occurring driver mutations impact clinical outcomes in blood cancers, but predicting the emergent effect of co-occurring mutations that impact multiple complex and interacting signalling networks is challenging....
3.
Jayawant E, Pack A, Clark H, Kennedy E, Ghodke A, Jones J, et al.
Front Oncol
. 2023 Jun;
13:1181660.
PMID: 37333821
Introduction: Improving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. Nuclear factor-κB (NF-κB) is frequently aberrantly activated in DLBCL. Transcriptionally active NF-κB...
4.
Cloete I, Smith V, Jackson R, Pepper A, Pepper C, Vogler M, et al.
NPJ Syst Biol Appl
. 2023 Jun;
9(1):23.
PMID: 37280330
In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this homeostasis is frequently perturbed in cancer cells due to the...
5.
ODonnell A, Pepper C, Mitchell S, Pepper A
Front Oncol
. 2023 Apr;
13:1169397.
PMID: 37064123
Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western world. Despite the positive clinical effects of new targeted therapies, CLL still remains an incurable and...
6.
Cuthill K, Zhang Y, Pepper A, Boelen L, Coulter E, Asquith B, et al.
Leukemia
. 2022 Jul;
36(9):2233-2241.
PMID: 35902732
Pathogenesis in chronic lymphocytic leukemia (CLL) is strongly linked to the potential for leukemic cells to migrate to and proliferate within lymph-nodes. Previous in vivo studies suggest that all leukemic...
7.
Burley T, Hesketh A, Bucca G, Kennedy E, Ladikou E, Towler B, et al.
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406371
The retention and re-migration of Chronic Lymphocytic Leukemia cells into cytoprotective and proliferative lymphoid niches is thought to contribute to the development of resistance, leading to subsequent disease relapse. The...
8.
Graham C, Jozwik A, Quartey-Papafio R, Ioannou N, Metelo A, Scala C, et al.
Leukemia
. 2021 Jun;
35(12):3581-3584.
PMID: 34145373
No abstract available.
9.
Townsend W, Pasikowska M, Yallop D, Phillips E, Patten P, Salisbury J, et al.
Haematologica
. 2019 Sep;
105(6):1593-1603.
PMID: 31537685
CD4 T-follicular helper cells are essential for the survival, proliferation, and differentiation of germinal center B cells and have been implicated in the pathogenesis of follicular lymphoma (FL). To further...
10.
Graham C, Jozwik A, Pepper A, Benjamin R
Cells
. 2018 Oct;
7(10).
PMID: 30275435
Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably B-acute lymphoblastic leukaemia (B-ALL) and...