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Andrea Paun

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Articles 25
Citations 626
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Recent Articles
1.
DeSouza-Vieira T, Pretti M, Lima Gomes P, Paula-Neto H, Goundry A, Nascimento M, et al.
PLoS Pathog . 2024 Oct; 20(10):e1012592. PMID: 39378227
Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release and phagocytosis. Enhanced neutrophil infiltration is associated with higher susceptibility to Leishmania infection,...
2.
Pessenda G, Ferreira T, Paun A, Kabat J, Amaral E, Kamenyeva O, et al.
bioRxiv . 2024 Oct; PMID: 39372777
In murine models of visceral leishmaniasis (VL), parasitization of resident Kupffer cells (resKCs) is responsible for early growth of in the liver, which leads to granuloma formation and eventual parasite...
3.
Paun A, Grigg M
bioRxiv . 2024 Jun; PMID: 38903118
The ability to discriminate infection between closely related species within the species complex, specifically and is critical to inform the clinical diagnosis and determine the most efficacious treatment modality. We...
4.
Costa Catta-Preta C, Ferreira T, Ghosh K, Paun A, Sacks D
Nat Commun . 2023 Nov; 14(1):7159. PMID: 37935664
Whole genome analysis of Leishmania hybrids generated experimentally in sand flies supports a meiotic mechanism of genetic exchange, with Mendelian segregation of the nuclear genome. Here, we perform functional analyses...
5.
Riyal H, Ferreira T, Paun A, Ghosh K, Samaranayake N, Sacks D, et al.
Acta Trop . 2023 Jun; 245:106979. PMID: 37391025
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of genus Leishmania, and transmitted by different species of Phlebotomine sand flies. More than 20 species of Leishmania are known...
6.
Lesani M, Gosmanov C, Paun A, Lewis M, McCall L
Metabolites . 2022 Sep; 12(9). PMID: 36144206
is an intracellular parasite with different species pathogenic to humans and causing the disease leishmaniasis. causes visceral leishmaniasis (VL) that manifests as hepatosplenomegaly, fever, pancytopenia and hypergammaglobulinemia. If left without...
7.
Paun A
Curr Protoc . 2022 Feb; 2(2):e367. PMID: 35182409
This protocol describes the culture of Leishmania parasites from skin biopsy samples of patients with cutaneous lesions. The use of antibiotics to prevent bacterial contamination of these cultures increases the...
8.
Louradour I, Ferreira T, Duge E, Karunaweera N, Paun A, Sacks D
Elife . 2022 Jan; 11. PMID: 34994687
are protozoan parasites transmitted by the bite of sand fly vectors producing a wide spectrum of diseases in their mammalian hosts. These diverse clinical outcomes are directly associated with parasite...
9.
Paun A, Claudio E, Siebenlist U
Blood Adv . 2021 Feb; 5(3):745-755. PMID: 33560391
There is a considerable body of work exploring the role of NF-κB family of transcription factors in the maturation and functions of later stage B cells; however, their role in...
10.
Lewis M, Paun A, Romano A, Langston H, Langner C, Moore I, et al.
PLoS Pathog . 2020 Apr; 16(4):e1008456. PMID: 32282850
Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment...