Andrea Paula-Lima
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Explore the profile of Andrea Paula-Lima including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
206
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Recent Articles
1.
Gleitze S, Ramirez O, Vega-Vasquez I, Stefan E, Bengtson C, Paula-Lima A, et al.
Biochem Biophys Res Commun
. 2025 Mar;
754:151445.
PMID: 40022811
The brain constantly adapts to environmental changes by modifying the expression of genes that enable synaptic plasticity, learning and memory. The expression of several of these genes requires nuclear calcium...
2.
Arriagada J, Merceron D, Ardiles A, Munoz P, Paula-Lima A
Biochem Biophys Res Commun
. 2024 Dec;
742:151133.
PMID: 39657347
Alzheimer's disease (AD) is characterized by the accumulation of soluble amyloid-β oligomers (AβOs) in the brain, which disrupt synaptic function and promote cognitive decline. Here, we investigated the effects of...
3.
Lobos P, Vega-Vasquez I, Bruna B, Gleitze S, Toledo J, Hartel S, et al.
Antioxidants (Basel)
. 2023 Nov;
12(11).
PMID: 38001825
Hippocampal neuronal activity generates dendritic and somatic Ca signals, which, depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial...
4.
Hidalgo C, Paula-Lima A
Trends Mol Med
. 2023 Nov;
30(1):25-36.
PMID: 37957056
Hippocampal synaptic plasticity is widely considered the cellular basis of learning and spatial memory processes. This article highlights the central role of Ca release from the endoplasmic reticulum (ER) in...
5.
Gleitze S, Ramirez O, Vega-Vasquez I, Yan J, Lobos P, Bading H, et al.
Antioxidants (Basel)
. 2023 Mar;
12(3).
PMID: 36978954
Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione peroxidase...
6.
Plaza-Rosales I, Brunetti E, Montefusco-Siegmund R, Madariaga S, Hafelin R, Ponce D, et al.
Front Aging Neurosci
. 2023 Feb;
15:1097577.
PMID: 36845655
Introduction: Alzheimer's disease (AD) is the leading cause of dementia worldwide, but its pathophysiological phenomena are not fully elucidated. Many neurophysiological markers have been suggested to identify early cognitive impairments...
7.
Vega-Vasquez I, Lobos P, Toledo J, Adasme T, Paula-Lima A, Hidalgo C
Biochem Biophys Res Commun
. 2022 Nov;
633:96-103.
PMID: 36344175
The hippocampus is a brain region implicated in synaptic plasticity and memory formation; both processes require neuronal Ca signals generated by Ca entry via plasma membrane Ca channels and Ca...
8.
Gleitze S, Paula-Lima A, Nunez M, Hidalgo C
Free Radic Biol Med
. 2021 Aug;
175:28-41.
PMID: 34461261
Iron, through its participation in oxidation/reduction processes, is essential for the physiological function of biological systems. In the brain, iron is involved in the development of normal cognitive functions, and...
9.
Lobos P, Cordova A, Vega-Vasquez I, Ramirez O, Adasme T, Toledo J, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34389673
The expression of several hippocampal genes implicated in learning and memory processes requires that Ca signals generated in dendritic spines, dendrites, or the soma in response to neuronal stimulation reach...
10.
Diaz-Zuniga J, More J, Melgar-Rodriguez S, Jimenez-Union M, Villalobos-Orchard F, Munoz-Manriquez C, et al.
Front Immunol
. 2020 Nov;
11:588036.
PMID: 33240277
Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota that colonizes the gingivodental sulcus....