Andrea Lelli
Overview
Explore the profile of Andrea Lelli including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
19
Citations
935
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Jean P, Wong Jun Tai F, Singh-Estivalet A, Lelli A, Scandola C, Megharba S, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(26):e2221744120.
PMID: 37339214
Functional molecular characterization of the cochlea has mainly been driven by the deciphering of the genetic architecture of sensorineural deafness. As a result, the search for curative treatments, which are...
2.
Calvet C, Peineau T, Benamer N, Cornille M, Lelli A, Plion B, et al.
iScience
. 2022 Dec;
25(12):105628.
PMID: 36483015
Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this...
3.
Boucher S, Wong Jun Tai F, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(49):31278-31289.
PMID: 33229591
Presbycusis, or age-related hearing loss (ARHL), is a major public health issue. About half the phenotypic variance has been attributed to genetic factors. Here, we assessed the contribution to presbycusis...
4.
Dunbar L, Patni P, Aguilar C, Mburu P, Corns L, Wells H, et al.
EMBO Mol Med
. 2019 Aug;
11(9):e10288.
PMID: 31448880
Hearing relies on mechanically gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and...
5.
CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival
Michel V, Booth K, Patni P, Cortese M, Azaiez H, Bahloul A, et al.
EMBO Mol Med
. 2017 Nov;
9(12):1711-1731.
PMID: 29084757
Defects of CIB2, calcium- and integrin-binding protein 2, have been reported to cause isolated deafness, DFNB48 and Usher syndrome type-IJ, characterized by congenital profound deafness, balance defects and blindness. We...
6.
Emptoz A, Michel V, Lelli A, Akil O, de Monvel J, Lahlou G, et al.
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9695-9700.
PMID: 28835534
Our understanding of the mechanisms underlying inherited forms of inner ear deficits has considerably improved during the past 20 y, but we are still far from curative treatments. We investigated...
7.
Lelli A, Michel V, de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, et al.
J Cell Biol
. 2016 Jan;
212(2):231-44.
PMID: 26754646
The precise architecture of hair bundles, the arrays of mechanosensitive microvilli-like stereocilia crowning the auditory hair cells, is essential to hearing. Myosin IIIa, defective in the late-onset deafness form DFNB30,...
8.
Behlouli A, Bonnet C, Abdi S, Bouaita A, Lelli A, Hardelin J, et al.
Orphanet J Rare Dis
. 2014 Apr;
9:55.
PMID: 24741995
Background: Almost 90% of all cases of congenital, non-syndromic, severe to profound inherited deafness display an autosomal recessive mode of transmission (DFNB forms). To date, 47 causal DFNB genes have...
9.
Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice
Sahly I, Dufour E, Schietroma C, Michel V, Bahloul A, Perfettini I, et al.
J Cell Biol
. 2012 Oct;
199(2):381-99.
PMID: 23045546
The mechanisms underlying retinal dystrophy in Usher syndrome type I (USH1) remain unknown because mutant mice lacking any of the USH1 proteins-myosin VIIa, harmonin, cadherin-23, protocadherin-15, sans-do not display retinal...
10.
Kawashima Y, Geleoc G, Kurima K, Labay V, Lelli A, Asai Y, et al.
J Clin Invest
. 2011 Nov;
121(12):4796-809.
PMID: 22105175
Inner ear hair cells convert the mechanical stimuli of sound, gravity, and head movement into electrical signals. This mechanotransduction process is initiated by opening of cation channels near the tips...