Andrea L Edwards
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Explore the profile of Andrea L Edwards including associated specialties, affiliations and a list of published articles.
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11
Citations
547
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Recent Articles
1.
Stevenson H, Makhov A, Calero M, Edwards A, Zeldin O, Mathews I, et al.
Proc Natl Acad Sci U S A
. 2014 May;
111(23):8470-5.
PMID: 24872454
The current practice for identifying crystal hits for X-ray crystallography relies on optical microscopy techniques that are limited to detecting crystals no smaller than 5 μm. Because of these limitations,...
2.
Trausch J, Xu Z, Edwards A, Reyes F, Ross P, Knight R, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(18):6624-9.
PMID: 24753586
In bacteria, sulfur metabolism is regulated in part by seven known families of riboswitches that bind S-adenosyl-l-methionine (SAM). Direct binding of SAM to these mRNA regulatory elements governs a downstream...
3.
Edwards A, Matsui T, Weiss T, Khosla C
J Mol Biol
. 2014 Apr;
426(11):2229-45.
PMID: 24704088
The 6-deoxyerythronolide B synthase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Saccharopolyspora erythraea that synthesizes the macrocyclic core of the antibiotic erythromycin 6-deoxyerythronolide B. The...
4.
Edwards A, Sangurdekar D, Jeong K, Khodursky A, Rybenkov V
PLoS One
. 2013 Dec;
8(12):e84027.
PMID: 24376785
MukB is a bacterial SMC (structural maintenance of chromosome) protein that regulates the global folding of the Escherichia coli chromosome by bringing distant DNA segments together. We report that moderate...
5.
Garst A, Edwards A, Batey R
Cold Spring Harb Perspect Biol
. 2010 Oct;
3(6).
PMID: 20943759
A critical feature of the hypothesized RNA world would have been the ability to control chemical processes in response to environmental cues. Riboswitches present themselves as viable candidates for a...
6.
Edwards A, Reyes F, Heroux A, Batey R
RNA
. 2010 Sep;
16(11):2144-55.
PMID: 20864509
S-adenosyl-(L)-homocysteine (SAH) riboswitches are regulatory elements found in bacterial mRNAs that up-regulate genes involved in the S-adenosyl-(L)-methionine (SAM) regeneration cycle. To understand the structural basis of SAH-dependent regulation by RNA,...
7.
Gilbert S, Reyes F, Edwards A, Batey R
Structure
. 2009 Jun;
17(6):857-68.
PMID: 19523903
Purine riboswitches discriminate between guanine and adenine by at least 10,000-fold based on the identity of a single pyrimidine (Y74) that forms a Watson-Crick base pair with the ligand. To...
8.
Edwards A, Garst A, Batey R
Methods Mol Biol
. 2009 Apr;
535:135-63.
PMID: 19377976
Structural biology plays a central role in gaining a full understanding of the myriad roles of RNA in biology. In recent years, innovative approaches in RNA purification and crystallographic methods...
9.
Edwards A, Batey R
J Mol Biol
. 2008 Nov;
385(3):938-48.
PMID: 19007790
Riboswitches are noncoding RNA elements that are commonly found in the 5'-untranslated region of bacterial mRNA. Binding of a small-molecule metabolite to the riboswitch aptamer domain guides the folding of...
10.
Gilbert S, Love C, Edwards A, Batey R
Biochemistry
. 2007 Oct;
46(46):13297-309.
PMID: 17960911
The purine riboswitch is one of a number of mRNA elements commonly found in the 5'-untranslated region capable of controlling expression in a cis-fashion via its ability to directly bind...