Andrea Kranz
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Explore the profile of Andrea Kranz including associated specialties, affiliations and a list of published articles.
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31
Citations
2160
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Recent Articles
1.
Hanna C, Huang J, Belton C, Reinhardt S, Dahl A, Andrews S, et al.
Nucleic Acids Res
. 2022 Feb;
50(4):1993-2004.
PMID: 35137160
Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene promoters and CpG islands. H3K4me3 is essential for mammalian development, yet mechanisms underlying its genomic targeting are...
2.
Grinat J, Kosel F, Goveas N, Kranz A, Alexopoulou D, Rajewsky K, et al.
Life Sci Alliance
. 2022 Jan;
5(4).
PMID: 35064075
Differentiation and lineage specification are controlled by cooperation of growth factor signalling. The involvement of epigenetic regulators in lineage specification remains largely elusive. Here, we show that the histone methyltransferase...
3.
Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, et al.
PLoS Genet
. 2021 Dec;
17(12):e1009250.
PMID: 34860830
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone...
4.
Michurina A, Sakib M, Kerimoglu C, Kruger D, Kaurani L, Islam M, et al.
EMBO J
. 2021 Nov;
41(1):e106459.
PMID: 34806773
In mammals, histone 3 lysine 4 methylation (H3K4me) is mediated by six different lysine methyltransferases. Among these enzymes, SETD1B (SET domain containing 1b) has been linked to syndromic intellectual disability...
5.
Grinat J, Heuberger J, Vidal R, Goveas N, Kosel F, Berenguer-Llergo A, et al.
Nat Commun
. 2020 Dec;
11(1):6422.
PMID: 33349639
Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of intestinal cancer stem cells. Here we identify the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1...
6.
Ashokkumar D, Zhang Q, Much C, Bledau A, Naumann R, Alexopoulou D, et al.
Development
. 2020 May;
147(12).
PMID: 32439762
Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system associated with gene expression. In mammals there are six H3K4 methyltransferases related to yeast Set1 and fly Trithorax,...
7.
Kranz A, Anastassiadis K
Biochim Biophys Acta Gene Regul Mech
. 2020 May;
1863(8):194578.
PMID: 32389824
The Trithorax-related Set1 H3K4 methyltransferases are conserved from yeast to human. In yeast loss of Set1 causes pleiotropic effects but is compatible with life. In contrast, both mammalian Set1 orthologs:...
8.
Zhu Q, Fang L, Heuberger J, Kranz A, Schipper J, Scheckenbach K, et al.
Cell Rep
. 2019 Jan;
26(2):415-428.e5.
PMID: 30625324
We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function...
9.
Percin G, Eitler J, Kranz A, Fu J, Pollard J, Naumann R, et al.
Nat Commun
. 2018 Dec;
9(1):5279.
PMID: 30538245
Regulatory mechanisms controlling the pool size of spleen dendritic cells (DC) remain incompletely understood. DCs are continuously replenished from hematopoietic stem cells, and FLT3-mediated signals cell-intrinsically regulate homeostatic expansion of...
10.
Chen Y, Jones K, Anastassiadis K, Kranz A, Stewart A, Grembecka J, et al.
Exp Hematol
. 2018 Oct;
69:37-42.
PMID: 30315824
Disrupting the protein-protein interaction for molecularly targeted cancer therapeutics can be a challenging but promising strategy. Compounds that disrupt the interaction between menin, a chromatin-binding protein, and oncogenic mixed lineage...