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Andrea Kirmaier

Explore the profile of Andrea Kirmaier including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 376
Followers 0
Related Specialties
Microbiology
General Medicine
Pathology
Top 10 Co-Authors
Welkin E Johnson
Vanessa M Hirsch
Fan Wu
Sonya Whitted
Kevin R McCarthy
Ramy Arnaout
Kenta Matsuda
Ilnour Ourmanov
Jennifer S Morgan
Stefan Riedel
Published In
PLoS Pathog
J Virol
Diagn Microbiol Infect Dis
Trends Microbiol
PLoS One
Affiliations
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Recent Articles
11.
Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface
McCarthy K, Kirmaier A, Autissier P, Johnson W
PLoS Pathog . 2015 Aug; 11(8):e1005085. PMID: 26291613
The widespread distribution of lentiviruses among African primates, and the lack of severe pathogenesis in many of these natural reservoirs, are taken as evidence for long-term co-evolution between the simian...
12.
Monkey-adapted HIV-1 highlights in vivo significance of restriction factors
Kirmaier A, Johnson W
Trends Microbiol . 2014 Aug; 22(9):486-7. PMID: 25127418
HIV-1 was isolated 31 years ago, yet models for studying HIV-1 pathogenesis in vivo are still lacking. Recent experiments using an HIV-1 strain engineered to replicate in macaques recapitulate several...
13.
TRIM5 alpha drives SIVsmm evolution in rhesus macaques
Wu F, Kirmaier A, Goeken R, Ourmanov I, Hall L, Morgan J, et al.
PLoS Pathog . 2013 Aug; 9(8):e1003577. PMID: 23990789
The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of the TRIM5α B30.2/SPRY domain impacted the level of...
14.
Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5α specificity
McCarthy K, Schmidt A, Kirmaier A, Wyand A, Newman R, Johnson W
PLoS Pathog . 2013 May; 9(5):e1003352. PMID: 23675300
Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5α(Q) , Trim5α(TFP) and Trim5(CypA) . Despite the high degree of amino acid identity...
15.
TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species
Kirmaier A, Wu F, Newman R, Hall L, Morgan J, OConnor S, et al.
PLoS Biol . 2010 Sep; 8(8). PMID: 20808775
Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed...
16.
Acquisition and processing of nonhuman primate samples for genetic and phylogenetic analyses
Kirmaier A, Diehl W, Johnson W
Methods . 2009 Jun; 49(1):5-10. PMID: 19508893
Primates have long been a favorite subject of evolutionary biologists, and in recent decades, have come to play an increasingly important role in biomedical research, including comparative genetics and phylogenetics....
17.
Evolution of a TRIM5-CypA splice isoform in old world monkeys
Newman R, Hall L, Kirmaier A, Pozzi L, Pery E, Farzan M, et al.
PLoS Pathog . 2008 Apr; 4(2):e1000003. PMID: 18389077
The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for...