Andrea Guidarelli
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Explore the profile of Andrea Guidarelli including associated specialties, affiliations and a list of published articles.
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61
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345
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Recent Articles
1.
Varone E, Retini M, Cherubini A, Chernorudskiy A, Marrazza A, Guidarelli A, et al.
Cell Death Dis
. 2025 Feb;
16(1):105.
PMID: 39962052
Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide...
2.
Spina A, Guidarelli A, Buffi G, Fiorani M, Cantoni O
Pharmacol Res
. 2024 Dec;
211():107554.
PMID: 39694125
This study focused on the interplay between NADPH oxidase 2 (NOX 2) activation and mitochondrial superoxide (mitoO) formation induced by clinically relevant concentrations of arsenic trioxide (ATO; AsO) in acute...
3.
Blandino G, Fiorani M, Canonico B, De Matteis R, Guidarelli A, Montanari M, et al.
Redox Biol
. 2023 Oct;
67:102915.
PMID: 37866162
Long-term treatment of schizophrenia with clozapine (CLZ), an atypical antipsychotic drug, is associated with an increased incidence of metabolic disorders mediated by poorly understood mechanisms. We herein report that CLZ,...
4.
Guidarelli A, Spina A, Buffi G, Blandino G, Fiorani M, Cantoni O
Chem Biol Interact
. 2023 Sep;
383:110694.
PMID: 37659621
A 6 h exposure of U937 cells to 2.5 μM arsenite stimulates low Ca release from the inositol 1, 4, 5-triphosphate receptor (IPR), causing a cascade of causally connected events,...
5.
Colomba M, Benedetti S, Fraternale D, Guidarelli A, Coppari S, Freschi V, et al.
Nutrients
. 2023 Jul;
15(9).
PMID: 37432298
In our previous studies, fruit (PSF) ethanol extract was showed to exert antioxidant, antimicrobial, anti-inflammatory and wound healing activities. In the present study, an integrated bioinformatics analysis combined with experimental...
6.
Guidarelli A, Spina A, Fiorani M, Zito E, Cantoni O
Environ Toxicol Pharmacol
. 2023 Feb;
98:104080.
PMID: 36781116
Arsenite is a potent carcinogen and toxic compound inducing an array of deleterious effects via different mechanisms, which include the Ca-dependent formation of reactive oxygen species. The mechanism whereby the...
7.
Germani S, Marchetti A, Guidarelli A, Cantoni O, Sorrentino V, Zito E
Sci Rep
. 2022 Nov;
12(1):20632.
PMID: 36450915
RYR1 is the gene encoding the ryanodine receptor 1, a calcium release channel of the endo/sarcoplasmic reticulum. I4898T in RYR1 is one of the most common mutations that give rise...
8.
Guidarelli A, Spina A, Fiorani M, Zito E, Cantoni O
Food Chem Toxicol
. 2022 Aug;
168:113360.
PMID: 35964836
Our recent studies suggest that arsenite stimulates the crosstalk between the inositol 1, 4, 5-triphosphate receptor (IPR) and the ryanodine receptor (RyR) via a mechanism dependent on endoplasmic reticulum (ER)...
9.
Cantoni O, Zito E, Guidarelli A, Fiorani M, Ghezzi P
Antioxidants (Basel)
. 2022 May;
11(5).
PMID: 35624898
Long-term ingestion of arsenicals, a heterogeneous group of toxic compounds, has been associated with a wide spectrum of human pathologies, which include various malignancies. Although their mechanism of toxicity remains...
10.
Spina A, Guidarelli A, Fiorani M, Varone E, Catalani A, Zito E, et al.
Biochem Pharmacol
. 2022 Feb;
198:114973.
PMID: 35189109
Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO) via a Ca-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate...