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Andrea B Kohn

Explore the profile of Andrea B Kohn including associated specialties, affiliations and a list of published articles. Areas
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Articles 46
Citations 1742
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Recent Articles
1.
Dabe E, Kohn A, Moroz L
Methods Mol Biol . 2024 Apr; 2757:447-460. PMID: 38668978
Epigenomic regulation and dynamic DNA methylation, in particular, are widespread mechanisms orchestrating the genome operation across time and species. Whole-genome bisulfite sequencing (WGBS) is currently the only method for unbiasedly...
2.
Kohn A, Moroz L
Methods Mol Biol . 2024 Apr; 2757:361-381. PMID: 38668976
Gap junction proteins form specialized intercellular communication channels, including electrical synapses, that regulate cellular metabolism and signaling. We present a molecular inventory of the gap junction proteins-innexins (INX-like) in ctenophores,...
3.
Kohn A, Bobkova Y, Moroz L
Methods Mol Biol . 2024 Apr; 2757:215-237. PMID: 38668969
In situ hybridization is a powerful and precise tool for revealing cell- and tissue-specific gene expression and a critical approach to validating single-cell RNA-seq (scRNA-seq). However, applying it to highly...
4.
Kohn A, Bobkova Y, Moroz L
Methods Mol Biol . 2024 Apr; 2757:201-214. PMID: 38668968
RNA-seq or transcriptome analysis of individual cells and small cell populations is essential for virtually any biomedical field. Here, we examine and discuss the different methods of RNA isolation specific...
5.
Moraga Amador D, Kohn A, Bobkova Y, Panayotova N, Moroz L
Methods Mol Biol . 2024 Apr; 2757:185-200. PMID: 38668967
Long-read sequencing has proven the necessity for high-quality genomic assemblies of reference species, including enigmatic ctenophores. Obtaining high-molecular-weight genomic DNA is pivotal to this process and has proven highly problematic...
6.
Corrales M, Cocanougher B, Kohn A, Wittenbach J, Long X, Lemire A, et al.
Neural Dev . 2022 Oct; 17(1):11. PMID: 36289550
No abstract available.
7.
Dillon N, Cocanougher B, Sood C, Yuan X, Kohn A, Moroz L, et al.
Neural Dev . 2022 Aug; 17(1):7. PMID: 36002894
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints....
8.
Corrales M, Cocanougher B, Kohn A, Wittenbach J, Long X, Lemire A, et al.
Neural Dev . 2022 Aug; 17(1):8. PMID: 36002881
Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate...
9.
Musser J, Schippers K, Nickel M, Mizzon G, Kohn A, Pape C, et al.
Science . 2021 Nov; 374(6568):717-723. PMID: 34735222
The evolutionary origin of metazoan cell types such as neurons and muscles is not known. Using whole-body single-cell RNA sequencing in a sponge, an animal without nervous system and musculature,...
10.
Moroz L, Nikitin M, Policar P, Kohn A, Romanova D
Neuropharmacology . 2021 Aug; 199:108740. PMID: 34343611
Glutamate (Glu) is the primary excitatory transmitter in the mammalian brain. But, we know little about the evolutionary history of this adaptation, including the selection of l-glutamate as a signaling...