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Andre Levchenko

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Articles 155
Citations 6916
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Recent Articles
1.
Scuderi S, Kang T, Jourdon A, Yang L, Wu F, Nelson A, et al.
bioRxiv . 2024 May; PMID: 38798404
The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural tube. To understand if recreating those axes was sufficient to...
2.
Pellowe A, Wu M, Kang T, Chung T, Ledesma-Mendoza A, Herzog E, et al.
Am J Pathol . 2024 Mar; 194(7):1171-1184. PMID: 38548268
Interactions between endothelial cells (ECs) and mural pericytes (PCs) are critical in maintaining the stability and function of the microvascular wall. Abnormal interactions between these two cell types are a...
3.
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A
Elife . 2024 Feb; 12. PMID: 38376371
Angiogenesis is a morphogenic process resulting in the formation of new blood vessels from pre-existing ones, usually in hypoxic micro-environments. The initial steps of angiogenesis depend on robust differentiation of...
4.
Obata T, Mizoguchi S, Greaney A, Adams T, Yuan Y, Edelstein S, et al.
bioRxiv . 2024 Jan; PMID: 38260691
Tissue homeostasis is controlled by cellular circuits governing cell growth, organization, and differentation. In this study we identify previously undescribed cell-to-cell communication that mediates information flow from mechanosensitive pleural mesothelial...
5.
Torborg S, Grbovic-Huezo O, Singhal A, Holm M, Wu K, Han X, et al.
bioRxiv . 2024 Jan; PMID: 38234855
Control of cell identity and number is central to tissue function, yet principles governing organization of malignant cells in tumor tissues remain poorly understood. Using mathematical modeling and candidate-based analysis,...
6.
Dighe A, Maziarz J, Ibrahim-Hashim A, Gatenby R, Kshitiz , Levchenko A, et al.
iScience . 2024 Jan; 27(1):108593. PMID: 38174318
Gene expression change is a dominant mode of evolution. Mutations, however, can affect gene expression in multiple cell types. Therefore, gene expression evolution in one cell type can lead to...
7.
Emadi A, Lipniacki T, Levchenko A, Abdi A
Biology (Basel) . 2023 Dec; 12(12). PMID: 38132287
A cell constantly receives signals and takes different fates accordingly. Given the uncertainty rendered by signal transduction noise, a cell may incorrectly perceive these signals. It may mistakenly behave as...
8.
Lee S, Yousafzai M, Mohler K, Yadav V, Amiri S, Szuszkiewicz J, et al.
Mol Biol Cell . 2023 Sep; 34(12):ar122. PMID: 37672340
The invasive potential of glioblastoma cells is attributed to large changes in pressure and volume, driven by diverse elements, including the cytoskeleton and ion cotransporters.  However, how the cell actuates...
9.
Zhou X, Cao H, Fang S, Chow R, Tang K, Majety M, et al.
Nat Immunol . 2023 Jul; 24(9):1499-1510. PMID: 37500885
Chimeric antigen receptor (CAR)-T cells are powerful therapeutics; however, their efficacy is often hindered by critical hurdles. Here utilizing the endocytic feature of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic tail,...
10.
Zhou X, Cao H, Fang S, Chow R, Tang K, Majety M, et al.
bioRxiv . 2023 Mar; PMID: 36993364
Chimeric antigen receptor (CAR) T cells are powerful therapeutics; however, their efficacy is often hindered by critical hurdles. Here, utilizing the endocytic feature of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic...