Andras Franko
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Explore the profile of Andras Franko including associated specialties, affiliations and a list of published articles.
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24
Citations
454
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Recent Articles
11.
Lubomirov L, Gagov H, Schroeter M, Wiesner R, Franko A
Physiol Rep
. 2019 Feb;
7(3):e13975.
PMID: 30740930
Diabetes mellitus (DM) is a metabolic disorder with high prevalence, and a major risk factor for macro- and microvascular abnormalities. This study was undertaken to explore the mechanisms of hypercontractility...
12.
Franko A, Merkel D, Kovarova M, Hoene M, Jaghutriz B, Heni M, et al.
Nutrients
. 2018 Sep;
10(9).
PMID: 30227635
Fatty liver is tightly associated with insulin resistance and the development of type 2 diabetes. I148M variant in patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene is associated with high liver...
13.
Franko A, Kovarova M, Feil S, Feil R, Wagner R, Heni M, et al.
Metabolism
. 2018 Sep;
88:22-30.
PMID: 30195474
Background: The activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrosis, however the role of HSCs is less understood in hepatic insulin resistance. Since in the...
14.
Rodriguez Camargo D, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, et al.
Chem Commun (Camb)
. 2018 May;
54(43):5426-5429.
PMID: 29745410
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP,...
15.
Wust S, Drose S, Heidler J, Wittig I, Klockner I, Franko A, et al.
Cell Metab
. 2018 Apr;
27(5):1026-1039.e6.
PMID: 29606596
Muscle stem cells undergo a dramatic metabolic switch to oxidative phosphorylation during differentiation, which is achieved by massively increased mitochondrial activity. Since expression of the muscle-specific miR-1/133a gene cluster correlates...
16.
Franko A, Rodriguez Camargo D, Boddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, et al.
Sci Rep
. 2018 Jan;
8(1):1116.
PMID: 29348618
The formation of amyloid fibrils by human islet amyloid polypeptide protein (hIAPP) has been implicated in pancreas dysfunction and diabetes. However, efficient treatment options to reduce amyloid fibrils in vivo...
17.
Franko A, Kunze A, Bose M, von Kleist-Retzow J, Paulsson M, Hartmann U, et al.
Int J Mol Sci
. 2017 May;
18(6).
PMID: 28556799
Mitochondria play a pivotal role in energy metabolism, but whether insulin signaling per se could regulate mitochondrial function has not been identified yet. To investigate whether mitochondrial function is regulated...
18.
Rodriguez Camargo D, Tripsianes K, Buday K, Franko A, Gobl C, Hartlmuller C, et al.
Sci Rep
. 2017 Mar;
7:44041.
PMID: 28287098
Type II diabetes (T2D) is characterized by diminished insulin production and resistance of cells to insulin. Among others, endoplasmic reticulum (ER) stress is a principal factor contributing to T2D and...
19.
Franko A, Neschen S, Rozman J, Rathkolb B, Aichler M, Feuchtinger A, et al.
Mol Metab
. 2017 Mar;
6(3):256-266.
PMID: 28271032
Objective: Recently, we have shown that Bezafibrate (BEZ), the pan-PPAR (peroxisome proliferator-activated receptor) activator, ameliorated diabetes in insulin deficient streptozotocin treated diabetic mice. In order to study whether BEZ can...
20.
Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, et al.
Diabetes
. 2016 Jun;
65(9):2540-52.
PMID: 27284107
Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), has been generally used to treat hyperlipidemia for decades. Clinical trials with type 2 diabetes patients indicated that BEZ also...