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Anders Malarstig

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Articles 79
Citations 5735
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Recent Articles
1.
Henry A, Mo X, Finan C, Chaffin M, Speed D, Issa H, et al.
Nat Genet . 2025 Mar; PMID: 40038546
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants...
2.
Wang W, Garofoli A, Ferrada E, Klimek C, Steurer B, Ingles-Prieto A, et al.
Life Sci Alliance . 2025 Jan; 8(4). PMID: 39884836
The human () gene encodes a plasma membrane protein SLC39A8 (ZIP8) that mediates the specific uptake of the metals Cd, Mn, Zn, Fe, Co, and Se Pathogenic variants within are...
3.
Coley K, Wang Q, Packer R, John C, Abner E, Reis K, et al.
Nicotine Tob Res . 2025 Jan; PMID: 39792440
Introduction: Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist with the highest therapeutic efficacy of any pharmacological smoking cessation aid and a 12-month cessation rate of 26%. Genetic variation...
4.
Repetto L, Chen J, Yang Z, Zhai R, Timmers P, Feng X, et al.
Nat Hum Behav . 2024 Aug; 8(11):2222-2234. PMID: 39210026
Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted...
5.
Desai T, Hedman A, Dimitriou M, Koprulu M, Figiel S, Yin W, et al.
EBioMedicine . 2024 Jun; 105:105168. PMID: 38878676
Background: Understanding the role of circulating proteins in prostate cancer risk can reveal key biological pathways and identify novel targets for cancer prevention. Methods: We investigated the association of 2002...
6.
Smith-Byrne K, Hedman A, Dimitriou M, Desai T, Sokolov A, Schioth H, et al.
Nat Commun . 2024 Apr; 15(1):3621. PMID: 38684708
Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head...
7.
Huang J, Osthushenrich T, MacNamara A, Malarstig A, Brocchetti S, Bradberry S, et al.
RSC Adv . 2024 Apr; 14(19):13083-13094. PMID: 38655474
The solute carrier transporter family 6 (SLC6) is of key interest for their critical role in the transport of small amino acids or amino acid-like molecules. Their dysfunction is strongly...
8.
Grassmann F, Malarstig A, Dahl L, Bendes A, Dale M, Thomas C, et al.
Br J Cancer . 2023 Dec; 130(4):620-627. PMID: 38135714
Objective: Current breast cancer risk prediction scores and algorithms can potentially be further improved by including molecular markers. To this end, we studied the association of circulating plasma proteins using...
9.
Ferrada E, Wiedmer T, Wang W, Frommelt F, Steurer B, Klimek C, et al.
J Mol Biol . 2023 Dec; 436(2):168383. PMID: 38070861
Creatine is an essential metabolite for the storage and rapid supply of energy in muscle and nerve cells. In humans, impaired metabolism, transport, and distribution of creatine throughout tissues can...
10.
Malarstig A, Grassmann F, Dahl L, Dimitriou M, McLeod D, Gabrielson M, et al.
Nat Commun . 2023 Nov; 14(1):7680. PMID: 37996402
Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but...