Anand S Bhagwat
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Explore the profile of Anand S Bhagwat including associated specialties, affiliations and a list of published articles.
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7
Citations
572
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Recent Articles
1.
Bhagwat A, Torres L, Shestova O, Shestov M, Mellors P, Fisher H, et al.
Nat Med
. 2024 Sep;
30(12):3697-3708.
PMID: 39333315
Acute myeloid leukemia (AML) is a rapidly progressive malignancy without effective therapies for refractory disease. So far, chimeric antigen receptor (CAR) T cell therapy in AML has not recapitulated the...
2.
Bhagwat A, Lu B, Vakoc C
Blood
. 2018 Feb;
131(16):1795-1804.
PMID: 29439951
Hematopoietic cancers are often initiated by deregulation of the transcriptional machinery. Prominent among such regulators are the sequence-specific DNA-binding transcription factors (TFs), which bind to enhancer and promoter elements in...
3.
Bhagwat A, Roe J, Mok B, Hohmann A, Shi J, Vakoc C
Cell Rep
. 2016 Apr;
15(3):519-530.
PMID: 27068464
The bromodomain and extraterminal (BET) protein BRD4 can physically interact with the Mediator complex, but the relevance of this association to the therapeutic effects of BET inhibitors in cancer is...
4.
Bhagwat A, Vakoc C
Trends Cancer
. 2015 Dec;
1(1):53-65.
PMID: 26645049
Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be highly effective in...
5.
Wang E, Kawaoka S, Roe J, Shi J, Hohmann A, Xu Y, et al.
Elife
. 2015 Apr;
4:e06377.
PMID: 25919951
Most mammalian transcription factors (TFs) and cofactors occupy thousands of genomic sites and modulate the expression of large gene networks to implement their biological functions. In this study, we describe...
6.
Bhagwat A, Vakoc C
Mol Cell
. 2014 Mar;
53(6):857-8.
PMID: 24656126
In this issue of Molecular Cell, Cheng et al. describe an unexpected role for the histone methyltransferases MLL3 and MLL4 in the repression of tissue-specific promoters, a function that prevents...
7.
Li H, Haurigot V, Doyon Y, Li T, Wong S, Bhagwat A, et al.
Nature
. 2011 Jun;
475(7355):217-21.
PMID: 21706032
Editing of the human genome to correct disease-causing mutations is a promising approach for the treatment of genetic disorders. Genome editing improves on simple gene-replacement strategies by effecting in situ...