Ana Rita Brochado
Overview
Explore the profile of Ana Rita Brochado including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1322
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0
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Recent Articles
1.
Garcia-Santamarina S, Kuhn M, Devendran S, Maier L, Driessen M, Mateus A, et al.
Cell
. 2024 Sep;
187(22):6346-6357.e20.
PMID: 39321801
Pharmaceuticals can directly inhibit the growth of gut bacteria, but the degree to which such interactions manifest in complex community settings is an open question. Here, we compared the effects...
2.
Brenzinger S, Airoldi M, Ogunleye A, Jugovic K, Amstalden M, Brochado A
Nat Microbiol
. 2024 Jan;
9(1):251-262.
PMID: 38172623
Toxic bacterial modules such as toxin-antitoxin systems hold antimicrobial potential, though successful applications are rare. Here we show that in Vibrio cholerae the cyclic-oligonucleotide-based anti-phage signalling system (CBASS), another example...
3.
Cacace E, Kim V, Varik V, Knopp M, Tietgen M, Brauer-Nikonow A, et al.
Nat Microbiol
. 2023 Sep;
8(11):2196-2212.
PMID: 37770760
Drug combinations can expand options for antibacterial therapies but have not been systematically tested in Gram-positive species. We profiled ~8,000 combinations of 65 antibacterial drugs against the model species Bacillus...
4.
Klunemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, et al.
Nature
. 2021 Sep;
597(7877):533-538.
PMID: 34497420
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently and the...
5.
Graw J, Engelhardt H, Kusel K, Kruck D, Tinnefeld P, Sander J, et al.
Biospektrum (Heidelb)
. 2021 Jul;
27(4):400-405.
PMID: 34219984
No abstract available.
6.
Domenech A, Brochado A, Sender V, Hentrich K, Henriques-Normark B, Typas A, et al.
Cell Host Microbe
. 2020 Mar;
27(4):544-555.e3.
PMID: 32130952
Streptococcus pneumoniae is a commensal of the human nasopharynx that can also cause severe antibiotic-resistant infections. Antibiotics drive the spread of resistance by inducing S. pneumoniae competence, in which bacteria...
7.
Brochado A, Telzerow A, Bobonis J, Banzhaf M, Mateus A, Selkrig J, et al.
Nature
. 2018 Jul;
559(7713):259-263.
PMID: 29973719
The spread of antimicrobial resistance has become a serious public health concern, making once-treatable diseases deadly again and undermining the achievements of modern medicine. Drug combinations can help to fight...
8.
Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson E, et al.
Nature
. 2018 Mar;
555(7698):623-628.
PMID: 29555994
A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Here, we screened more than 1,000...
9.
Brochado A, Patil K
Methods Mol Biol
. 2014 Apr;
1152:281-94.
PMID: 24744040
Identification of metabolic engineering strategies for rerouting intracellular fluxes towards a desired product is often a challenging task owing to the topological and regulatory complexity of metabolic networks. Genome-scale metabolic...
10.
Ezraty B, Vergnes A, Banzhaf M, Duverger Y, Huguenot A, Brochado A, et al.
Science
. 2013 Jul;
340(6140):1583-7.
PMID: 23812717
All bactericidal antibiotics were recently proposed to kill by inducing reactive oxygen species (ROS) production, causing destabilization of iron-sulfur (Fe-S) clusters and generating Fenton chemistry. We find that the ROS...