An T H Le
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Explore the profile of An T H Le including associated specialties, affiliations and a list of published articles.
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10
Citations
39
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Recent Articles
1.
Le A, Teclemichael E, Krylova S, Krylov S
JACS Au
. 2024 Dec;
4(12):4910-4920.
PMID: 39735910
Maintaining stringent conditions in SELEX (Systematic Evolution of Ligands by EXponential enrichment) is crucial for obtaining high-affinity aptamers. However, excessive stringency greatly increases the risk of SELEX failure. Controlling stringency...
2.
Wang T, Ji H, Everton D, Le A, Krylova S, Fournier R, et al.
Anal Chem
. 2023 Oct;
95(42):15826-15832.
PMID: 37831482
The equilibrium constant of a chemical reaction is arguably the key thermodynamic parameter in chemistry; we naturally expect that equilibrium constants are determined accurately. The majority of equilibrium constants determined...
3.
Teclemichael E, Le A, Krylova S, Wang T, Krylov S
Anal Chem
. 2022 Oct;
94(44):15183-15188.
PMID: 36302212
Selection of oligonucleotide aptamers involves consecutive rounds of affinity isolation of target-binding oligonucleotides from a random-sequence oligonucleotide library. Every next round produces an aptamer-enriched library with progressively higher fitness for...
4.
Wang T, Rukundo J, Le A, Ivanov N, Le Blanc J, Gorin B, et al.
Anal Chem
. 2022 Oct;
94(44):15415-15422.
PMID: 36301587
Large molecules can be generically separated from small ones, though partially and temporarily, in a pressure-driven flow inside a capillary. This transient incomplete separation has been only applied to species...
5.
Le A, Wang T, Krylova S, Beloborodov S, Krylov S
Anal Chem
. 2022 Jan;
94(5):2578-2588.
PMID: 35073041
Partitioning of protein-DNA complexes from protein-unbound DNA is a key step in selection of DNA aptamers. Conceptually, the partitioning step is characterized by two parameters: transmittance for protein-bound DNA (binders)...
6.
Le A, Krylova S, Beloborodov S, Wang T, Hili R, Johnson P, et al.
Anal Chem
. 2021 Mar;
93(13):5343-5354.
PMID: 33764056
Screening molecular libraries for ligands capable of binding proteins is widely used for hit identification in the early drug discovery process. Oligonucleotide libraries provide a very high diversity of compounds,...
7.
Le A, Krylova S, Krylov S
Anal Chem
. 2019 May;
91(13):8532-8539.
PMID: 31136154
Ideal-filter capillary electrophoresis (IFCE) allows selection of protein binders from oligonucleotide libraries in a single step of partitioning in which protein-bound and unbound oligonucleotides move in the opposite directions. In...
8.
Le A, Krylova S, Krylov S
Electrophoresis
. 2019 May;
40(18-19):2553-2564.
PMID: 31069842
Selection of affinity ligands for protein targets from oligonucleotide libraries currently involves multiple rounds of alternating steps of partitioning of protein-bound oligonucleotides (binders) from protein-unbound oligonucleotides (nonbinders). We have recently...
9.
Le A, Krylova S, Kanoatov M, Desai S, Krylov S
Angew Chem Int Ed Engl
. 2018 Dec;
58(9):2739-2743.
PMID: 30577082
Selection of aptamers from oligonucleotide libraries currently requires multiple rounds of alternating steps of partitioning of binders from nonbinders and enzymatic amplification of all collected oligonucleotides. Herein, we report a...
10.
Kochmann S, Le A, Hili R, Krylov S
Electrophoresis
. 2018 Aug;
39(23):2991-2996.
PMID: 30152876
Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) is an affinity method for separating binder-target complexes from nonbinders by gel-free CE. NECEEM is a promising high-efficiency method for partitioning protein binders...