Amit Vaish
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Explore the profile of Amit Vaish including associated specialties, affiliations and a list of published articles.
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14
Citations
58
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Recent Articles
1.
Fotsch C, Basu D, Case R, Chen Q, Koneru P, Lo M, et al.
SLAS Discov
. 2024 May;
29(4):100159.
PMID: 38723666
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay...
2.
Ingersoll J, Shcherbakov A, Vaish A, Poppe L
ACS Med Chem Lett
. 2023 Aug;
14(8):1063-1066.
PMID: 37583825
Biophysical research plays a crucial role in drug discovery, but many druglike molecules are poorly soluble and prone to aggregation, making their analysis challenging and susceptible to artifacts. To address...
3.
Wurz R, Rui H, Dellamaggiore K, Ghimire-Rijal S, Choi K, Smither K, et al.
Nat Commun
. 2023 Jul;
14(1):4177.
PMID: 37443112
Targeted protein degradation via "hijacking" of the ubiquitin-proteasome system using proteolysis targeting chimeras (PROTACs) has evolved into a novel therapeutic modality. The design of PROTACs is challenging; multiple steps involved...
4.
Zhang H, Huang C, Yu X, Lee J, Vaish A, Chen Q, et al.
Commun Biol
. 2021 May;
4(1):526.
PMID: 33953337
The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis. Here, we present the cryo-EM...
5.
Vaish A, Lin J, McBride H, Grandsard P, Chen Q
Anal Biochem
. 2020 Oct;
609:113974.
PMID: 33010205
Antibody-based therapeutics targeting membrane proteins have evolved as a major modality for the treatment of cancer, inflammation and autoimmune diseases. There are numerous challenges, ranging from desired epitope expression to...
6.
Lippens J, Egea P, Spahr C, Vaish A, Keener J, Marty M, et al.
Anal Chem
. 2018 Oct;
90(22):13616-13623.
PMID: 30335969
Therapeutic target characterization involves many components, including accurate molecular weight (MW) determination. Knowledge of the accurate MW allows one to detect the presence of post-translational modifications, proteolytic cleavages, and importantly,...
7.
Vaish A, Guo S, Murray R, Grandsard P, Chen Q
Anal Biochem
. 2018 Jun;
556:70-77.
PMID: 29936096
Despite the significant role integral membrane proteins (IMPs) play in the drug discovery process, it remains extremely challenging to express, purify, and in vitro stabilize them for detailed biophysical analyses....
8.
Vaish A, Vanderah D, Richter L, Dimitriou M, Steffens K, Walker M
Chem Commun (Camb)
. 2015 Mar;
51(30):6591-4.
PMID: 25774882
We present a facile strategy to modify poly(dopamine) (PDA)-coated substrates. Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting...
9.
Vaish A, Vanderah D, Vierling R, Crawshaw F, Gallagher D, Walker M
Colloids Surf B Biointerfaces
. 2014 Aug;
122:552-558.
PMID: 25124834
As part of an effort to develop biointerfaces for structure-function studies of integral membrane proteins (IMPs) a series of oligo(ethylene oxide) self-assembled monolayers (OEO-SAMs) were evaluated for their resistance to...
10.
Vaish A, Silin V, Walker M, Steffens K, Krueger S, Yeliseev A, et al.
Chem Commun (Camb)
. 2013 Feb;
49(26):2685-7.
PMID: 23435270
We have developed a method based on self-assembly of thiols on Au substrates to immobilize membrane proteins at interfaces. Using water soluble nitrilotriacetic acid (NTA)-terminated oligo(ethylene glycol) thiols, a histidine-tagged...