Amir M Ashique
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Explore the profile of Amir M Ashique including associated specialties, affiliations and a list of published articles.
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16
Citations
758
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Recent Articles
1.
Rodriguez B, Huang J, Gibson L, Fradette J, Chen H, Koyano K, et al.
Mol Cancer Ther
. 2024 Apr;
23(8):1144-1158.
PMID: 38648067
We recently reported that resistance to PD-1 blockade in a refractory lung cancer-derived model involved increased collagen deposition and the collagen-binding inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR1). Thus, we...
2.
Tian J, Ashique A, Weeks S, Lan T, Yang H, Chen H, et al.
Cancer Immunol Res
. 2024 Feb;
12(5):592-613.
PMID: 38393969
Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact. Immunoglobulin-like transcript (ILT)2 and ILT4 are related immune-suppressive receptors that play a...
3.
Koosha E, Brenna C, Ashique A, Jain N, Ovens K, Koike T, et al.
Development
. 2023 Dec;
151(2).
PMID: 38117077
During endochondral ossification, chondrocytes secrete a proteoglycan (PG)-rich extracellular matrix that can inhibit the process of cartilage maturation, including expression of Ihh and Col10a1. Because bone morphogenetic proteins (BMPs) can...
4.
Ashique A, Atake O, Ovens K, Guo R, Pratt I, Detrich 3rd H, et al.
J Anat
. 2021 Aug;
240(1):34-49.
PMID: 34423431
Ancestors of the Antarctic icefishes (family Channichthyidae) were benthic and had no swim bladder, making it energetically expensive to rise from the ocean floor. To exploit the water column, benthopelagic...
5.
Harrison K, Hiebert B, Panahifar A, Andronowski J, Ashique A, King G, et al.
J Bone Miner Res
. 2020 Jul;
35(11):2211-2228.
PMID: 32614975
Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide...
6.
Ashique A, May S, Kane M, Folias A, Phamluong K, Choe Y, et al.
Genesis
. 2011 Dec;
50(5):415-23.
PMID: 22162152
Retinoic acid (RA) signaling is necessary for proper patterning and morphogenesis during embryonic development. Tissue-specific RA signaling requires precise spatial and temporal synthesis of RA from retinal by retinaldehyde dehydrogenases...
7.
Speca D, Chihara D, Ashique A, Bowers M, Pierce-Shimomura J, Lee J, et al.
PLoS Genet
. 2010 Aug;
6(8).
PMID: 20714347
The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe the positional cloning and characterization of a new mouse mutation isolated in...
8.
Endoh-Yamagami S, Karkar K, May S, Cobos I, Thwin M, Long J, et al.
Dev Biol
. 2010 Jan;
340(1):41-53.
PMID: 20096683
Precise control of neuronal migration is essential for proper function of the brain. Taking a forward genetic screen, we isolated a mutant mouse with defects in interneuron migration. By genetic...
9.
Ashique A, Choe Y, Karlen M, May S, Phamluong K, Solloway M, et al.
Sci Signal
. 2009 Nov;
2(95):ra70.
PMID: 19887680
Regulatory factor X (Rfx) homologs regulate the transcription of genes necessary for ciliogenesis in invertebrates and vertebrates. Primary cilia are necessary for Hedgehog signaling and regulation of the activity of...
10.
Siegenthaler J, Ashique A, Zarbalis K, Patterson K, Hecht J, Kane M, et al.
Cell
. 2009 Nov;
139(3):597-609.
PMID: 19879845
Extrinsic signals controlling generation of neocortical neurons during embryonic life have been difficult to identify. In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial...