Ami Khanal Lamichhane
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Explore the profile of Ami Khanal Lamichhane including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
125
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Recent Articles
1.
Yang D, Khanal Lamichhane A, Kwon-Chung K, Chang Y
mBio
. 2023 Jan;
14(1):e0345122.
PMID: 36656038
Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and cytosine deaminase are known major players in flucytosine...
2.
Chang Y, Khanal Lamichhane A, Cai H, Walter P, Bennett J, Kwon-Chung K
Nat Commun
. 2021 Jun;
12(1):3418.
PMID: 34103502
The antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci...
3.
Khanal Lamichhane A, Garraffo H, Cai H, Walter P, Kwon-Chung K, Chang Y
mBio
. 2019 Aug;
10(4).
PMID: 31455652
We found a novel role of Myo5, a type I myosin (myosin-I), and its fortuitous association with d-amino acid utilization in Myo5 colocalized with actin cortical patches and was required...
4.
Chang Y, Khanal Lamichhane A, Kwon-Chung K
mBio
. 2018 Dec;
9(6).
PMID: 30514783
Heteroresistance to fluconazole (FLC) in is a transient adaptive resistance which is lost upon release from the drug pressure. It is known that clones heteroresistant to FLC invariably contain disomic...
5.
Chang M, Sionov E, Khanal Lamichhane A, Kwon-Chung K, Chang Y
Antimicrob Agents Chemother
. 2018 Jan;
62(4).
PMID: 29378705
and species complexes are the etiologic agents of cryptococcosis. We have deciphered the roles of three ABC transporters, Afr1, Afr2, and Mdr1, in the representative strains of the two species,...
6.
Chang Y, Khanal Lamichhane A, Bradley J, Rodgers L, Ngamskulrungroj P, Kwon-Chung K
PLoS One
. 2015 Jul;
10(7):e0131865.
PMID: 26132227
The ability to grow on media containing certain D-amino acids as a sole nitrogen source is widely utilized to differentiate Cryptococcus gattii from C. neoformans. We used the C. neoformans...
7.
Chang Y, Khanal Lamichhane A, Garraffo H, Walter P, Leerkes M, Kwon-Chung K
PLoS Genet
. 2014 Apr;
10(4):e1004292.
PMID: 24762475
Cryptococcus neoformans encounters a low oxygen environment when it enters the human host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine nucleotide exchange factor...
8.
Role of actin-bundling protein Sac6 in growth of Cryptococcus neoformans at low oxygen concentration
Chang Y, Khanal Lamichhane A, Kwon-Chung K
Eukaryot Cell
. 2012 May;
11(7):943-51.
PMID: 22562467
Cryptococcus neoformans, the etiologic agent of cryptococcosis, is an obligately aerobic yeast that inhabits an environmental niche exposed to ambient air. The cell doubling time was significantly prolonged under 1%...
9.
Lee H, Khanal Lamichhane A, Garraffo H, Kwon-Chung K, Chang Y
Mol Microbiol
. 2012 Feb;
84(1):130-46.
PMID: 22339665
This study shows the importance of PDK1, TOR and PKC signalling pathways to the basal tolerance of Cryptococcus neoformans towards fluconazole, the widely used drug for treatment of cryptococcosis. Mutations...