Amelia J Brennan
Overview
Explore the profile of Amelia J Brennan including associated specialties, affiliations and a list of published articles.
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23
Citations
391
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Recent Articles
1.
Lelliott E, Naddaf J, Ganio K, Michie J, Wang S, Liu L, et al.
Cell Death Differ
. 2024 Sep;
31(12):1707-1716.
PMID: 39261596
Tumour immune evasion presents a significant challenge to the effectiveness of cancer immunotherapies. Recent advances in high-throughput screening techniques have uncovered that loss of antigen presentation and cytokine signalling pathways...
2.
Rudd-Schmidt J, Laine R, Noori T, Brennan A, Voskoboinik I
Front Immunol
. 2023 Jan;
13:931820.
PMID: 36618385
When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing. The pore-forming perforin is essential...
3.
Lelliott E, Ramsbottom K, Dowling M, Shembrey C, Noori T, Kearney C, et al.
Front Immunol
. 2022 Jul;
13:931630.
PMID: 35874669
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating...
4.
Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
Castiblanco D, Rudd-Schmidt J, Noori T, Sutton V, Hung Y, Flinsenberg T, et al.
Blood
. 2022 Jan;
139(12):1833-1849.
PMID: 35081253
Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol transporter, NPC1. Despite typically presenting with pronounced neurological manifestations, NP-C1 also resembles...
5.
Brennan A, Law R, Conroy P, Noori T, Lukoyanova N, Saibil H, et al.
Cell Death Differ
. 2018 Feb;
25(8):1517-1529.
PMID: 29416110
The pore forming, Ca-dependent protein, perforin, is essential for the function of cytotoxic lymphocytes, which are at the frontline of immune defence against pathogens and cancer. Perforin is a glycoprotein...
6.
House I, House C, Brennan A, Gilan O, Dawson M, Whisstock J, et al.
EMBO Rep
. 2017 Aug;
18(10):1775-1785.
PMID: 28808112
Perforin is a highly cytotoxic pore-forming protein essential for immune surveillance by cytotoxic lymphocytes. Prior to delivery to target cells by exocytosis, perforin is stored in acidic secretory granules where...
7.
Sharp J, Brennan A, Polekhina G, Ascher D, Lefevre C, Nicholas K
Cell Signal
. 2017 Feb;
33:86-97.
PMID: 28193539
α-lactalbumin is a protein of dual function found in milk of most mammals. α-lactalbumin binds β-1,4-galactosyltransferase to form the regulatory subunit for lactose synthesis and has also been shown to...
8.
Leung C, Hodel A, Brennan A, Lukoyanova N, Tran S, House C, et al.
Nat Nanotechnol
. 2017 Feb;
12(5):467-473.
PMID: 28166206
Perforin is a key protein of the vertebrate immune system. Secreted by cytotoxic lymphocytes as soluble monomers, perforin can self-assemble into oligomeric pores of 10-20 nm inner diameter in the...
9.
Kearney C, Brennan A, Darcy P, Oliaro J
Crit Rev Immunol
. 2016 Jan;
35(4):325-47.
PMID: 26757394
A synapse is a specialized structure that forms when the plasma membrane of two cells come into close contact to facilitate communication and signaling. Cells of the immune system form...
10.
Sutton V, Brennan A, Ellis S, Danne J, Thia K, Jenkins M, et al.
FEBS J
. 2016 Jan;
283(5):947-61.
PMID: 26756195
The anionic proteoglycan serglycin is a major constituent of secretory granules in cytotoxic T lymphocyte (CTL)/natural killer (NK) cells, and is proposed to promote the safe storage of the mostly...