Amber L Southwell
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Explore the profile of Amber L Southwell including associated specialties, affiliations and a list of published articles.
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46
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1685
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Recent Articles
1.
A tool to automate assessment of regional brain atrophy in mouse models of neurodegenerative disease
Moldenhauer S, Potluri N, Xie Y, Southwell A
bioRxiv
. 2024 Dec;
PMID: 39651151
As life expectancy rises, so too does the prevalence of neurodegenerative diseases. Neurodegeneration causes progressive regional brain atrophy, typically initiating prior to symptom onset. Researchers measure the impact of potential...
2.
Harding R, Xie Y, Caron N, Findlay-Black H, Lyu C, Potluri N, et al.
bioRxiv
. 2024 Oct;
PMID: 39386513
Huntington disease (HD) is a progressive and devastating neurodegenerative disease caused by expansion of a glutamine-coding CAG tract in the huntingtin () gene above a critical threshold of ~35 repeats...
3.
Bartl S, Xie Y, Potluri N, Kesineni R, Hencak K, Cengio L, et al.
Neurobiol Dis
. 2024 Feb;
193:106444.
PMID: 38402018
No abstract available.
4.
Bartl S, Xie Y, Potluri N, Kesineni R, Hencak K, Cengio L, et al.
Neurobiol Dis
. 2023 Dec;
190:106376.
PMID: 38092268
In Huntington disease (HD), the mutant huntingtin (mtHTT) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. mtHTT is ubiquitously expressed and there is,...
5.
Rook M, Southwell A
BioDrugs
. 2022 Mar;
36(2):105-119.
PMID: 35254632
Huntington disease (HD) is a fatal progressive neurodegenerative disorder caused by an inherited mutation in the huntingtin (HTT) gene, which encodes mutant HTT protein. Though HD remains incurable, various preclinical...
6.
Caron N, Banos R, Aly A, Xie Y, Ko S, Potluri N, et al.
Neurobiol Dis
. 2022 Feb;
166:105652.
PMID: 35143966
Huntington disease (HD) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the HTT gene encoding an elongated polyglutamine tract in the huntingtin (HTT) protein. Expanded mutant HTT...
7.
Ravalia A, Lau J, Barron J, Purchase S, Southwell A, Hayden M, et al.
Neurobiol Dis
. 2021 Feb;
152:105293.
PMID: 33556538
Synaptic structure and function are compromised prior to cell death and symptom onset in a variety of neurodegenerative diseases. In Huntington disease (HD), a CAG repeat expansion in the gene...
8.
Caron N, Banos R, Yanick C, Aly A, Byrne L, Smith E, et al.
J Neurosci
. 2020 Dec;
41(4):780-796.
PMID: 33310753
Huntington disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide repeat expansion in the huntingtin () gene. Therapeutics that lower HTT have shown preclinical promise and are being...
9.
Machiela E, Jeloka R, Caron N, Mehta S, Schmidt M, Baddeley H, et al.
Front Aging Neurosci
. 2020 Nov;
12:524369.
PMID: 33192449
Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin () gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs...
10.
Machiela E, Southwell A
J Huntingtons Dis
. 2020 May;
9(2):115-128.
PMID: 32417788
Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin gene (HTT). While mutant HTT is present ubiquitously throughout life, HD onset typically occurs...