Amarnath S Marudamuthu
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Explore the profile of Amarnath S Marudamuthu including associated specialties, affiliations and a list of published articles.
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12
Citations
311
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Recent Articles
1.
Gopal U, Monroe J, Marudamuthu A, Begum S, Walters B, Stewart R, et al.
Cells
. 2023 Apr;
12(7).
PMID: 37048068
Leptomeningeal disease occurs when cancer cells migrate into the ventricles of the brain and spinal cord and then colonize the meninges of the central nervous system. The triple-negative subtype of...
2.
Nagaraja M, Tiwari N, Shetty S, Marudamuthu A, Fan L, Ostrom R, et al.
Am J Pathol
. 2018 Sep;
188(10):2207-2222.
PMID: 30253845
Idiopathic pulmonary fibrosis (IPF) is a debilitating, incurable, and life-threatening disease. A cardinal feature of the pathogenesis of IPF is excessive extracellular matrix deposition attributable to proliferation of activated fibrotic...
3.
Shetty S, Tiwari N, Marudamuthu A, Puthusseri B, Bhandary Y, Fu J, et al.
Am J Pathol
. 2017 Mar;
187(5):1016-1034.
PMID: 28273432
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. The pathogenesis of interstitial lung diseases, including its most common form, IPF, remains poorly understood. Alveolar epithelial cell...
4.
Tiwari N, Marudamuthu A, Tsukasaki Y, Ikebe M, Fu J, Shetty S
Am J Physiol Lung Cell Mol Physiol
. 2016 Jan;
310(6):L496-506.
PMID: 26747783
We previously demonstrated that tumor suppressor protein p53 augments plasminogen activator inhibitor-1 (PAI-1) expression in alveolar epithelial cells (AECs) during chronic cigarette smoke (CS) exposure-induced lung injury. Chronic lung inflammation...
5.
Bhandary Y, Shetty S, Marudamuthu A, Midde K, Ji H, Shams H, et al.
PLoS One
. 2015 May;
10(5):e0123187.
PMID: 25932922
Parenchymal lung inflammation and airway and alveolar epithelial cell apoptosis are associated with cigarette smoke exposure (CSE), which contributes to chronic obstructive pulmonary disease (COPD). Epidemiological studies indicate that people...
6.
Marudamuthu A, Shetty S, Bhandary Y, Karandashova S, Thompson M, Sathish V, et al.
J Biol Chem
. 2015 Feb;
290(15):9428-41.
PMID: 25648892
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive interstitial scarification. A hallmark morphological lesion is the accumulation of myofibroblasts or fibrotic lung fibroblasts (FL-fibroblasts) in areas...
7.
Bhandary Y, Shetty S, Marudamuthu A, Fu J, Pinson B, Levin J, et al.
Toxicol Appl Pharmacol
. 2015 Jan;
283(2):92-8.
PMID: 25596429
Silica is the major component of airborne dust generated by wind, manufacturing and/or demolition. Chronic occupational inhalation of silica dust containing crystalline quartz is by far the predominant form of...
8.
Bhandary Y, Shetty S, Marudamuthu A, Ji H, Neuenschwander P, Boggaram V, et al.
Am J Pathol
. 2013 May;
183(1):131-43.
PMID: 23665346
Alveolar type II epithelial cell (ATII) apoptosis and proliferation of mesenchymal cells are the hallmarks of idiopathic pulmonary fibrosis, a devastating disease of unknown cause characterized by alveolar epithelial injury...
9.
Shetty S, Bhandary Y, Marudamuthu A, Abernathy D, Velusamy T, Starcher B, et al.
Am J Respir Cell Mol Biol
. 2012 May;
47(4):474-83.
PMID: 22592924
Increased expression of tumor suppressor protein p53 and of plasminogen activator inhibitor (PAI)-1 is associated with cigarette smoke (CS) exposure-induced lung epithelial injury. p53 induces PAI-1 through mRNA stabilization in...
10.
Shetty S, Marudamuthu A, Abernathy D, Shetty R, Shetty P, Fu J, et al.
Biochemistry
. 2011 Dec;
51(1):205-13.
PMID: 22166006
Urokinase-type plasminogen activator (uPA) is expressed by lung epithelial cells and regulates fibrin turnover and epithelial cell viability. PMA, LPS, and TNF-alpha, as well as uPA itself, induce uPA expression...