Amanda J Roberts
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Explore the profile of Amanda J Roberts including associated specialties, affiliations and a list of published articles.
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117
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Recent Articles
1.
Wolfe S, Ma Y, Pilo C, Chang C, Ghassemian M, Roberts A, et al.
bioRxiv
. 2025 Feb;
PMID: 39990445
Summary: New mouse model of Spinocerebellar Ataxia Type 14 containing a clinically relevant mutation in PKCγ identified underlying drivers of the disease and neuroprotection in females.
2.
Jones J, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, et al.
J Biol Chem
. 2024 Sep;
300(10):107756.
PMID: 39260699
Aminoacyl-tRNA synthetases are fundamental to the translation machinery with emerging roles in transcriptional regulation. Previous cellular studies have demonstrated tyrosyl-tRNA synthetase (YARS1 or TyrRS) as a stress response protein through...
3.
Alvarez-Kuglen M, Ninomiya K, Qin H, Rodriguez D, Fiengo L, Farhy C, et al.
Nat Aging
. 2024 Aug;
4(9):1308-1327.
PMID: 39210148
For efficient, cost-effective and personalized healthcare, biomarkers that capture aspects of functional, biological aging, thus predicting disease risk and lifespan more accurately and reliably than chronological age, are essential. We...
4.
Lim E, Fallon R, Bates C, Ideguchi Y, Nagasaki T, Handzlik M, et al.
Cell Metab
. 2024 Aug;
36(10):2315-2328.e6.
PMID: 39191258
Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient supply during fasting and other stresses. These pathways are regulated locally in tissues and systemically via the liver, kidney,...
5.
Patel R, Gandhi P, Spencer K, Salem N, Erikson C, Borgonetti V, et al.
Neurobiol Stress
. 2024 Jul;
31:100657.
PMID: 38983690
Chronic ethanol dependence and withdrawal activate corticotropin releasing factor (CRF)-containing GABAergic neurons in the medial prefrontal cortex (mPFC), which tightly regulate glutamatergic pyramidal neurons. Using male CRF1:GFP reporter mice, we...
6.
Chen X, Becker A, Albay R, Nguyen P, Karachentsev D, Roberts A, et al.
Ann Neurol
. 2024 May;
96(2):390-404.
PMID: 38747498
Objectives: Due to increased gene dose for the amyloid precursor protein (APP), elderly adults with Down syndrome (DS) are at a markedly increased risk of Alzheimer's disease (AD), known as...
7.
Yuan N, Medders K, Sanchez A, Shah R, de Rozieres C, Ojeda-Juarez D, et al.
Brain Behav Immun
. 2024 Feb;
118:149-166.
PMID: 38423397
Macrophages (MΦ) infected with human immunodeficiency virus (HIV)-1 or activated by its envelope protein gp120 exert neurotoxicity. We found previously that signaling via p38 mitogen-activated protein kinase (p38 MAPK) is...
8.
Singh H, Koury J, Maung R, Roberts A, Kaul M
Brain Behav Immun
. 2024 Feb;
118:1-21.
PMID: 38360376
Human immunodeficiency virus-1 (HIV-1) infects the central nervous system (CNS) and causes HIV-associated neurocognitive disorders (HAND) in about half of the population living with the virus despite combination anti-retroviral therapy...
9.
Siddiqi M, Podder D, Pahng A, Athanason A, Nadav T, Cates-Gatto C, et al.
Addict Neurosci
. 2023 Dec;
9.
PMID: 38152067
Alcohol use disorder (AUD) produces cognitive deficits, indicating a shift in prefrontal cortex (PFC) function. PFC glutamate neurotransmission is mostly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic receptors (AMPARs); however preclinical studies...
10.
Okhuarobo A, Kreifeldt M, Gandhi P, Lopez C, Martinez B, Fleck K, et al.
Mol Psychiatry
. 2023 Dec;
29(2):529-542.
PMID: 38135755
Large conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders....