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Amanda Graveline

Explore the profile of Amanda Graveline including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 665
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Recent Articles
1.
Kapate N, Dunne M, Kumbhojkar N, Prakash S, Wang L, Graveline A, et al.
Proc Natl Acad Sci U S A . 2023 Apr; 120(17):e2221535120. PMID: 37075071
Multiple sclerosis (MS) is an incurable autoimmune disease and is currently treated by systemic immunosuppressants with off-target side effects. Although aberrant myeloid function is often observed in MS plaques in...
2.
Langellotto F, Dellacherie M, Yeager C, Ijaz H, Yu J, Cheng C, et al.
Adv Healthc Mater . 2021 Oct; 10(22):e2101370. PMID: 34605223
The coronavirus disease 2019 (COVID-19) pandemic demonstrates the importance of generating safe and efficacious vaccines that can be rapidly deployed against emerging pathogens. Subunit vaccines are considered among the safest,...
3.
Leeper K, Kalhor K, Vernet A, Graveline A, Church G, Mali P, et al.
Nat Protoc . 2021 Mar; 16(4):2088-2108. PMID: 33692551
Classic approaches to mapping the developmental history of cells in vivo have relied on techniques that require complex interventions and often capture only a single trajectory or moment in time....
4.
Ng A, Khoshakhlagh P, Rojo Arias J, Pasquini G, Wang K, Swiersy A, et al.
Nat Biotechnol . 2020 Dec; 39(4):510-519. PMID: 33257861
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types and tissues. To enable systematic exploration of the programming landscape mediated by transcription factors (TFs), we...
5.
Davidsohn N, Pezone M, Vernet A, Graveline A, Oliver D, Slomovic S, et al.
Proc Natl Acad Sci U S A . 2019 Nov; 116(47):23505-23511. PMID: 31685628
Comorbidity is common as age increases, and currently prescribed treatments often ignore the interconnectedness of the involved age-related diseases. The presence of any one such disease usually increases the risk...
6.
Papa A, Jiang A, Korin N, Chen M, Langan E, Waterhouse A, et al.
Sci Transl Med . 2019 Feb; 11(479). PMID: 30760580
Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation...
7.
Kalhor R, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, et al.
Science . 2018 Aug; 361(6405). PMID: 30093604
In vivo barcoding using nuclease-induced mutations is a powerful approach for recording biological information, including developmental lineages; however, its application in mammalian systems has been limited. We present in vivo...
8.
Li A, Sobral M, Badrinath S, Choi Y, Graveline A, Stafford A, et al.
Nat Mater . 2018 Mar; 17(6):528-534. PMID: 29507416
Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact peptide presentation and result in vaccine variability. Here, we report...
9.
Cartwright M, Rottman M, Shapiro N, Seiler B, Lombardo P, Gamini N, et al.
EBioMedicine . 2016 Jun; 9:217-227. PMID: 27333027
Background: Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a...
10.
Jain A, Graveline A, Waterhouse A, Vernet A, Flaumenhaft R, Ingber D
Nat Commun . 2016 Jan; 7:10176. PMID: 26733371
Accurate assessment of blood haemostasis is essential for the management of patients who use extracorporeal devices, receive anticoagulation therapy or experience coagulopathies. However, current monitoring devices do not measure effects...