Amanda Eustace
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Explore the profile of Amanda Eustace including associated specialties, affiliations and a list of published articles.
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10
Citations
422
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Recent Articles
1.
Yang L, Taylor J, Eustace A, Irlam J, Denley H, Hoskin P, et al.
Clin Cancer Res
. 2017 Apr;
23(16):4761-4768.
PMID: 28400426
Hypoxia modification improves overall survival in muscle-invasive bladder cancer patients who undergo radiotherapy. There is evidence that hypoxic tumors benefit most from hypoxia modification. The study aimed to identify or...
2.
Burrows N, Williams J, Telfer B, Resch J, Valentine H, Fitzmaurice R, et al.
Oncotarget
. 2016 Aug;
7(39):63106-63123.
PMID: 27527858
Anaplastic (ATC) and certain follicular thyroid-carcinomas (FTCs) are radioresistant. The Phosphatidylinositide 3-kinase (PI3K) pathway is commonly hyperactivated in thyroid-carcinomas. PI3K can modify the PI3K-related kinases (PIKKs) in response to radiation:...
3.
Eustace A, Mani N, Span P, Irlam J, Taylor J, Betts G, et al.
Clin Cancer Res
. 2013 Jul;
19(17):4879-88.
PMID: 23820108
Purpose: Tumor hypoxia is associated with a poor prognosis, hypoxia modification improves outcome, and hypoxic status predicts benefit from treatment. Yet, there is no universal measure of clinical hypoxia. The...
4.
Eustace A, Irlam J, Taylor J, Denley H, Agrawal S, Choudhury A, et al.
Radiother Oncol
. 2013 Jun;
108(1):40-7.
PMID: 23773411
Background And Purpose: Addition of carbogen and nicotinamide (hypoxia-modifying agents) to radiotherapy improves the survival of patients with high risk bladder cancer. The study investigated whether histopathological tumour features and...
5.
Hughes C, Iqbal-Wahid J, Brown M, Shanks J, Eustace A, Denley H, et al.
J Biophotonics
. 2012 Nov;
6(1):73-87.
PMID: 23125109
Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma...
6.
Betts G, Eustace A, Patiar S, Valentine H, Irlam J, Ramachandran A, et al.
Eur J Cancer
. 2012 Sep;
49(1):156-65.
PMID: 22951015
Background And Purpose: Tumour hypoxia is associated with a poor prognosis in head and neck squamous cell carcinoma (HNSCC), however there is no accepted method for assessing hypoxia clinically. We...
7.
Nishioka T, Eustace A, West C
Cell Struct Funct
. 2012 Mar;
37(1):75-80.
PMID: 22453058
In this mini-review, we discuss the physiological and pathological roles of lysyl oxidase (LOX) and its family, LOX-like proteins (LOXL), in relation to prognosis of major cancers. The number of...
8.
Eustace A, Smyth L, Mitchell L, Williamson K, Plumb J, Singh D
Chest
. 2010 Sep;
139(5):1089-1100.
PMID: 20864612
Background: Lymphocytes secrete IL-17A and IL-17F, which enhance innate immune responses. IL-17 expression has not been studied in COPD small airways. The aim of this study was to quantify IL-17A...
9.
Smyth L, Eustace A, Kolsum U, Blaikely J, Singh D
Chest
. 2010 May;
138(4):905-12.
PMID: 20453071
Background: T regulatory cells (Tregs) may play a role in the suppression of effector lymphocyte activity in asthma. We hypothesized that Treg numbers would be increased in patients with more...
10.
Brown L, Cowen R, Debray C, Eustace A, Erler J, Sheppard F, et al.
Mol Pharmacol
. 2005 Oct;
69(2):411-8.
PMID: 16254058
The resistance of hypoxic cells to conventional chemotherapy is well documented. Using both adenovirus-mediated gene delivery and small molecules targeting hypoxia-inducible factor-1 (HIF-1), we evaluated the impact of HIF-1 inhibition...